Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 3/20 | 0.42 |
| ▸ | AHR | P35869 | 3/20 | 0.41 |
| ▸ | CMA1 | P23946 | 2/20 | 0.41 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680978 | 0.90 | PDE3B (0.47) | AHRBRD4CREBBPTDP2PDK2 | |
| SCHEMBL13680598 | 0.76 | CRBN (0.50) | CRBNAHRCMA1EIF2AK2S1PR1 | |
| SCHEMBL13681000 | 0.76 | CRBN (0.40) | CRBNAHRCMA1EIF2AK2S1PR1 | |
| SCHEMBL13680968 | 0.73 | ALDH1A1 (0.35) | ALDH1A1MAPTPKMKDM4EHPGD | |
| SCHEMBL13680969 | 0.72 | GSK3B (0.43) | — | |
| SCHEMBL13681001 | 0.72 | HSD17B1 (0.44) | ALDH1A1MAPTPKMKDM4EHPGD | |
| SCHEMBL13680976 | 0.71 | MAPT (0.50) | PDE3BPDE3AALDH1A1MAPTPKM | |
| SCHEMBL13680985 | 0.71 | PRF1 (0.52) | MAPT | |
| SCHEMBL13681029 | 0.70 | ALDH1A1 (0.36) | ALDH1A1MAPTPKMKDM4EHPGD | |
| SCHEMBL13680864 | 0.69 | ALDH1A1 (0.63) | ALDH1A1MAPTPKMKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |