Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 16/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14761353 | 0.81 | PRF1 (0.62) | PRF1ACHEMAPTLMNAGAA | |
| SCHEMBL13681001 | 0.81 | HSD17B1 (0.44) | PRF1MAPT | |
| SCHEMBL13680969 | 0.79 | GSK3B (0.43) | PRF1 | |
| SCHEMBL6103756 | 0.76 | KCNJ1 (0.62) | PRF1ACHEMAPTLMNAGAA | |
| SCHEMBL13680993 | 0.76 | PRF1 (0.53) | PRF1ACHEMAPTLMNAGAA | |
| SCHEMBL13680592 | 0.75 | PRF1 (0.55) | PRF1ACHEMAPTLMNAGAA | |
| SCHEMBL13680968 | 0.74 | ALDH1A1 (0.35) | MAPT | |
| SCHEMBL13680978 | 0.73 | PDE3B (0.47) | — | |
| SCHEMBL13680859 | 0.73 | ALDH1A1 (0.60) | MAPTLMNA | |
| SCHEMBL13680973 | 0.71 | CRBN (0.42) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |