Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.46 |
| ▸ | PIM1 | P11309 | 7/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.46 |
| ▸ | GSK3A | P49840 | 6/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.46 |
| ▸ | MARK3 | P27448 | 3/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 4/20 | 0.45 |
| ▸ | CLK2 | P49760 | 4/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680986 | 0.81 | GUSB (0.45) | CHEK1 | |
| SCHEMBL13681003 | 0.80 | HRH3 (0.39) | CDK5CDK5R1 | |
| SCHEMBL13680995 | 0.79 | CDC25A (0.48) | DYRK1A | |
| SCHEMBL13680996 | 0.75 | QPCT (0.44) | QPCTQPCTL | |
| SCHEMBL13681010 | 0.74 | PDE3B (0.50) | CDK2 | |
| SCHEMBL13680997 | 0.74 | RAB9A (0.41) | DYRK1A | |
| SCHEMBL13680984 | 0.74 | LMNA (0.39) | CDK8TRPA1 | |
| SCHEMBL13680926 | 0.73 | LMNA (0.56) | MAPK1 | |
| SCHEMBL13680922 | 0.73 | GFER (0.62) | — | |
| SCHEMBL13680943 | 0.73 | RAB9A (0.48) | PIM1CDK5CDK5R1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |