Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430367 | 0.83 | POLB (0.54) | LMNAPOLBNPC1RAB9AALDH1A1 | |
| SCHEMBL13683098 | 0.82 | KIF11 (0.39) | POLBNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16200083 | 0.79 | ALDH1A1 (0.48) | LMNAP2RX7CYP11B2ALDH1A1CYP2A6 | |
| SCHEMBL14039660 | 0.77 | POLB (0.41) | LMNAPOLBSMN1; SMN2CYP11B2CYP1A2 | |
| SCHEMBL16200054 | 0.77 | P2RX7 (0.45) | P2RX7NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL13066524 | 0.76 | MEN1 (0.46) | POLB | |
| SCHEMBL13066522 | 0.76 | SMN1; SMN2 (0.46) | LMNAP2RX7POLBSMN1; SMN2 | |
| SCHEMBL28851687 | 0.74 | P2RX7 (0.43) | LMNAP2RX7NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13682914 | 0.72 | P2RX7 (0.44) | LMNAP2RX7POLBNPC1RAB9A | |
| SCHEMBL16200074 | 0.71 | POLB (0.40) | LMNAPOLBSMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589199-B2 | Substituted piperazines | CHEMOCENTRYX, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |