Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14139212 | 0.85 | POLB (0.40) | POLBHSD11B1PDE10ACYP1A2CYP2D6 | |
| SCHEMBL13430367 | 0.80 | POLB (0.54) | POLBLMNAPTGS1PTGS2CYP1A2 | |
| SCHEMBL16200058 | 0.76 | HSD11B1 (0.40) | POLBHSD11B1PDE10ACYP1A2MBNL1 | |
| SCHEMBL13066522 | 0.75 | SMN1; SMN2 (0.46) | POLBLMNASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL13682914 | 0.75 | P2RX7 (0.44) | POLBLMNAPDE10ASMN1; SMN2CYP1A2 | |
| SCHEMBL14039660 | 0.74 | POLB (0.41) | POLBLMNASMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL13683098 | 0.72 | KIF11 (0.39) | POLBSMN1; SMN2PTGS1PTGS2 | |
| SCHEMBL13066524 | 0.72 | MEN1 (0.46) | POLBPTGS1PTGS2 | |
| SCHEMBL13738167 | 0.71 | MAPT (0.40) | HSD11B1SMN1; SMN2MBNL1 | |
| SCHEMBL13683096 | 0.71 | LMNA (0.46) | POLBLMNASMN1; SMN2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |