Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17451417 | 0.80 | HCAR3 (0.41) | HCAR3TDP1HCAR2PTK2NNMT | |
| SCHEMBL7238262 | 0.79 | HCAR3 (0.44) | PTGS1FTOKDM4CKDM5BKDM2A | |
| SCHEMBL6434747 | 0.79 | CCNT1 (0.41) | PTGS1FTOKDM4CKDM5BKDM2A | |
| SCHEMBL4596035 | 0.78 | HCAR3 (0.71) | HCAR3HCAR2 | |
| SCHEMBL13685163 | 0.78 | PTGS1 (0.40) | PTGS1FTOKDM4CKDM5BKDM2A | |
| SCHEMBL114189 | 0.77 | PTK2 (0.62) | PTGS1TDP1PTK2 | |
| SCHEMBL29657055 | 0.77 | PTK2 (0.62) | PTGS1TDP1PTK2 | |
| SCHEMBL2643405 | 0.76 | ADRA2A (0.54) | PTGS1FTOKDM4CKDM5BKDM2A | |
| SCHEMBL3862877 | 0.75 | LMNA (0.47) | HCAR3 | |
| SCHEMBL30639140 | 0.75 | HRH4 (0.45) | PTGS1FTOKDM4CKDM5BKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963313-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | MADRIGAL PHARMACEUTICALS INC (US) | 2012-11-14 | — | — | EP | claimed |
| EP-1963313-B1 | INHIBITORS OF DIACYLGLYCEROL ACYLTRANSFERASE (DGAT) | MADRIGAL PHARMACEUTICALS INC (US) | 2012-11-14 | — | — | EP | disclosed |