Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | PGR | P06401 | 4/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.67 |
| ▸ | AR | P10275 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | TNF | P01375 | 1/20 | 0.67 |
| ▸ | IL6 | P05231 | 1/20 | 0.67 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.67 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.67 |
| ▸ | GLUL | P15104 | 1/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7145316 | 0.98 | HIF1A (0.79) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL7613021 | 0.98 | HIF1A (0.79) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL7142738 | 0.98 | HIF1A (0.79) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL11090884 | 0.98 | HIF1A (0.79) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL7985 | 0.98 | HIF1A (0.80) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL677625 | 0.96 | HIF1A (0.82) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL10363483 | 0.96 | HIF1A (0.82) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL6715060 | 0.94 | HIF1A (0.73) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| Prednisolone Acetate SCHEMBL9838659 | 0.93 | HIF1A (0.86) | HIF1ALMNAPGRSMN1; SMN2POLB | |
| SCHEMBL16018292 | 0.93 | HIF1A (0.85) | HIF1ALMNAPGRSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 666 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) | 2025-07-22 | — | — | US | claimed |
| US-20120058979-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | ZALICUS INC. (US) | 2012-03-08 | — | — | US | claimed |
| US-20120028910-A1 | STORAGE-STABLE AQUEOUS OPHTHALMIC FORMULATIONS | FOVEA PHARMACEUTICALS (FR) | 2012-02-02 | — | — | US | claimed |
| US-8080553-B2 | Methods and reagents for the treatment of immunoinflammatory disorders | ZALICUS INC. (US) | 2011-12-20 | — | — | US | claimed |
| EP-2301628-A1 | Methods and reagents for the treatment of immunoinflammatory disorders | Zalicus Inc. (US) | 2011-03-30 | — | — | EP | claimed |
| EP-2205248-A2 | COMBINATION OF NITRODERIVATIZED STEROID AND BRONCHODILATOR FOR TREATING RESPIRATORY DISEASE | Nicox S.A. (FR) | 2010-07-14 | — | — | EP | claimed |
| EP-2070550-A1 | Use of combinations comprising a corticosteroid and a pyrimidopyrimidine in the treatment of inflammatory diseases | Combinatorx, Incorporated (US) | 2009-06-17 | — | — | EP | claimed |
| WO-2009071990-A2 | NO-DONATING CORDICOSTEROID WITH IMPROVED PHARMACOKINETIC, ANTI-INFLAMMATORY AND VASODILATORY PROPERTIES | TOPIGEN PHARMACEUTICALS INC. (US) | 2009-06-11 | — | — | WO | claimed |
| US-20090087425-A1 | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease | TOPIGEN PHARMACEUTICALS INC. (CA) | 2009-04-02 | — | — | US | claimed |
| US-20090088411-A1 | No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties | TOPIGEN PHARMACEUTICALS INC. (CA) | 2009-04-02 | — | — | US | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| EP-0900233-A1 | NOVEL STEROID NITRITE AND NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1999-03-10 | — | — | EP | claimed |
| EP-0786999-A4 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO INC (US) | 1999-01-20 | — | — | EP | claimed |
| EP-0792371-A4 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO INC (US) | 1998-12-30 | — | — | EP | claimed |
| WO-1997041144-A1 | NOVEL STEROID NITRITE AND NITRATE ESTER DERIVATIVES USEFUL AS ANTI-INFLAMMATORY DRUGS | G.D. SEARLE & CO. (US) | 1997-11-06 | — | — | WO | claimed |
| EP-0792371-A1 | COMBINATION METHOD FOR ACNE TREATMENT | Merck & Co., Inc. (US) | 1997-09-03 | — | — | EP | claimed |
| EP-0786999-A1 | COMBINATION METHOD FOR ACNE TREATMENT | Merck & Co., Inc. (US) | 1997-08-06 | — | — | EP | claimed |
| WO-1996012817-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| WO-1996012487-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| EP-0496520-A1 | Novel bone acting agents | MERCK & CO. INC. (US) | 1992-07-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | STAT3, JAK2, JAK1 | HIF1A 4476/4885LMNA 4823/4885PGR 2826/4885 |
| US-20090088411-A1 | No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties | NOS1, NOS2, NOS3 | HIF1A 268/4885LMNA 3321/4885PGR 557/4885 |
| US-20090087425-A1 | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease | HSD11B1, HSD11B2, CYP11B1 | HIF1A 1235/4885LMNA 3384/4885PGR 1152/4885 |
| US-20120058979-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF IMMUNOINFLAMMATORY DISORDERS | IL5, TPMT, TSLP | HIF1A 1602/4885LMNA 3888/4885PGR 2470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.