Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057691 | 0.89 | TSHR (0.48) | HPGDTSHRHSD11B1HTR1A | |
| SCHEMBL4056913 | 0.86 | CYP3A4 (0.47) | KMT2A | |
| SCHEMBL4368252 | 0.83 | HTR1A (0.42) | HPGDTSHRHSD11B1HTR1AKMT2A | |
| SCHEMBL13690494 | 0.82 | TSHR (0.41) | TSHRHTR1A | |
| SCHEMBL13690619 | 0.81 | ATR (0.41) | TSHRHTR1A | |
| SCHEMBL4054057 | 0.81 | SIRT6 (0.33) | KMT2A | |
| SCHEMBL13690386 | 0.75 | NAMPT (0.33) | — | |
| SCHEMBL4057842 | 0.75 | HTR1A (0.43) | HPGDTSHRHSD11B1HTR1A | |
| SCHEMBL13690725 | 0.74 | L3MBTL3 (0.46) | KMT2A | |
| SCHEMBL4057361 | 0.74 | GPR119 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009106561-A1 | PYRAZINE COMPOUNDS FOR TREATING GPR119 RELATED DISORDERS | BIOVITRUM AB (PUBL) (SE) | 2009-09-03 | — | — | WO | disclosed |