Nb-001

Nb-001

SCHEMBL13697544

Nc1ncnc2c1ncn2CCNCCCCCO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ ADCY1 Q08828 1/20 1.00
▸ ALDH1A1 P00352 1/20 0.77
▸ ADORA2A P29274 8/20 0.71
▸ ADORA1 P30542 3/20 0.66
▸ ADCY5 O95622 4/20 0.55
▸ ADORA2B P29275 1/20 0.55
▸ AHCY P23526 4/20 0.53
▸ BACE1 P56817 1/20 0.52
▸ PI4KA P42356 1/20 0.50
▸ PI4K2B Q8TCG2 1/20 0.50
▸ PI4K2A Q9BTU6 1/20 0.50
▸ PI4KB Q9UBF8 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nb-001 SCHEMBL29886392 1.00 ADCY1 (1.00) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL29087636 0.99 ADCY1 (0.97) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL29087571 0.88 ALDH1A1 (0.79) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL8467390 0.86 ADORA2A (0.88) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL29930375 0.86 ALDH1A1 (0.97) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL19553487 0.85 ADORA2A (0.91) ADCY1ADORA2AADORA1ADCY5ADORA2B
SCHEMBL20558510 0.85 ADCY1 (0.73) ADCY1ALDH1A1ADORA2AADORA1ADCY5
SCHEMBL1635576 0.83 ADORA2A (1.00) ADCY1ADORA2AADORA1ADCY5ADORA2B
SCHEMBL29459142 0.80 ADORA2A (1.00) ADCY1ADORA2AADORA1ADCY5ADORA2B
SCHEMBL984944 0.80 ADORA2A (1.00) ADCY1ADORA2AADORA1ADCY5ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 121 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3279200-B1 CRYSTAL OF 5-((2-(6-AMINO)-9H-PURIN-9-YL)ETHYL)AMINO)PENTAN-1-OL FOREVER CHEER HOLDING LTD (HK) 2024-09-04 — — EP claimed
CN-114984020-B Use of adenylate cyclase inhibitors for the treatment of epilepsy and related disorders 永展控股有限公司 2024-08-30 — — CN claimed
CN-115998745-B Use of an adenylate cyclase inhibitor NB001 in the manufacture of a medicament for the treatment of pain and anxiety associated with Parkinson's disease 永展控股有限公司 2024-05-14 — — CN claimed
CN-114931561-B Capsule composition for treating chronic pain and preparation method thereof 青岛永展医药科技有限公司 2024-02-02 — — CN claimed
CN-115998745-A Use of an adenylate cyclase inhibitor NB001 in the manufacture of a medicament for the treatment of pain and anxiety associated with Parkinson's disease 永展控股有限公司 2023-04-25 — — CN claimed
CN-115990167-A Application of adenylate cyclase inhibitor NB001 in preparation of medicine for treating migraine and anxiety 永展控股有限公司 2023-04-21 — — CN claimed
US-11541060-B2 Pharmaceutical compositions for treating pain Forever Cheer Holding Limited (HK) 2023-01-03 — — US claimed
CN-114984020-A Use of adenylate cyclase inhibitors for the treatment of epilepsy and related disorders 永展控股有限公司 2022-09-02 — — CN claimed
CN-114931561-A Capsule composition for treating chronic pain and preparation method thereof 青岛永展医药科技有限公司 2022-08-23 — — CN claimed
EP-3403674-B1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN FOREVER CHEER INTERNATIONAL LTD (HK) 2021-06-30 — — EP claimed
US-20200268766-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN Forever Cheer Holding Limited (HK) 2020-08-27 — — US claimed
US-20180333420-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN FOREVER CHEER INTERNATIONAL LTD (HK) 2018-11-22 — — US claimed
EP-3403674-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN Forever Cheer International Limited (HK) 2018-11-21 — — EP claimed
US-20160257930-A1 NEURONAL STEM CELL DIFFERENTIATION UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2016-09-08 — — US claimed
EP-3058064-A1 NEURONAL STEM CELL DIFFERENTIATION University College Cardiff Consultants Limited (GB) 2016-08-24 — — EP claimed
WO-2015055987-A1 NEURONAL STEM CELL DIFFERENTIATION UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED (GB) 2015-04-23 — — WO claimed
CN-122020546-A Port group multisource heterogeneous data fusion and transportation channel digitizing method and system 交通运输部规划研究院 2026-05-12 — — CN disclosed
US-20260069707-A1 COMBINATION THERAPY WITH ANTIBODY-DRUG CONJUGATES AND HYALURONIDASES HALOZYME, INC. (US) 2026-03-12 — — US disclosed
US-20090233922-A1 Method for Treating Neuronal and Non-Neuronal Pain FOREVER CHEER INTERNATIONAL LIMITED (HK) 2009-09-17 — — US disclosed
WO-2007041863-A1 METHOD FOR TREATING NEURONAL AND NON-NEURONAL PAIN ZHUO MIN (CA) 2007-04-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200268766-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN OPRM1, OPRL1, OPRD1 ADCY1 37/4885ALDH1A1 384/4885ADORA2A 511/4885
US-20260069707-A1 COMBINATION THERAPY WITH ANTIBODY-DRUG CONJUGATES AND HYALURONIDASES CD22, CD2, CD44 ADCY1 2228/4885ALDH1A1 417/4885ADORA2A 1282/4885
US-11541060-B2 Pharmaceutical compositions for treating pain OPRM1, OPRL1, OPRD1 ADCY1 37/4885ALDH1A1 384/4885ADORA2A 511/4885
US-20090233922-A1 Method for Treating Neuronal and Non-Neuronal Pain OPRL1, ADCY1, GRIN1 ADCY1 2/4885ALDH1A1 603/4885ADORA2A 704/4885
US-20180333420-A1 PHARMACEUTICAL COMPOSITIONS FOR TREATING PAIN OPRM1, OPRL1, OPRD1 ADCY1 37/4885ALDH1A1 384/4885ADORA2A 511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback