Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278660 | 0.84 | ALDH1A1 (0.41) | LMNATDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL6335755 | 0.83 | LMNA (0.43) | LMNATDP1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL31403787 | 0.83 | ALDH1A1 (0.45) | LMNATDP1ALDH1A1MAPTHTT | |
| SCHEMBL439716 | 0.81 | LMNA (0.59) | LMNATDP1L3MBTL1ALDH1A1MAPT | |
| SCHEMBL6333835 | 0.79 | EDNRB (0.42) | LMNATDP1L3MBTL1EDNRBEDNRA | |
| SCHEMBL13713681 | 0.77 | NUDT1 (0.50) | LMNATDP1L3MBTL1EDNRBEDNRA | |
| SCHEMBL19330247 | 0.77 | ALDH1A1 (0.38) | LMNATDP1L3MBTL1EDNRBEDNRA | |
| SCHEMBL19330187 | 0.77 | ALDH1A1 (0.35) | LMNATDP1L3MBTL1EDNRBEDNRA | |
| SCHEMBL30701161 | 0.77 | ALDH1A1 (0.35) | LMNATDP1L3MBTL1EDNRBEDNRA | |
| SCHEMBL6333728 | 0.75 | L3MBTL1 (0.48) | LMNATDP1L3MBTL1EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595343-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2009-09-29 | — | — | US | disclosed |