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Meprednisone

Meprednisone

SCHEMBL13723450

C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3C(=O)C[C@]2(C)[C@@]1(O)C(=O)CO.C[C@]12C=CC(=O)C=C1C(Cl)=C[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Meprednisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 9/20 0.68
▸ PGR P06401 8/20 0.68
▸ NR1I2 O75469 3/20 0.68
▸ MLNR O43193 1/20 0.68
▸ ADORA3 P0DMS8 1/20 0.68
▸ HTR2C P28335 1/20 0.68
▸ HSD17B10 Q99714 6/20 0.59
▸ HIF1A Q16665 6/20 0.59
▸ KMT2A Q03164 2/20 0.59
▸ ALDH1A1 P00352 2/20 0.59
▸ LMNA P02545 2/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ SLC29A1 Q99808 1/20 0.59
▸ TDP1 Q9NUW8 1/20 0.59
▸ CYP3A4 P08684 3/20 0.57
▸ ABCB11 O95342 2/20 0.57
▸ AR P10275 2/20 0.57
▸ SERPINA6 P08185 2/20 0.57
▸ TNF P01375 1/20 0.57
▸ IL6 P05231 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Meprednisone SCHEMBL16759699 0.84 HSD17B10 (0.83) NR3C1PGRNR1I2HSD17B10HIF1A
Methylprednisolone SCHEMBL17223638 0.84 NR3C1 (0.70) NR3C1PGRNR1I2HSD17B10HIF1A
Cloprednol SCHEMBL3999177 0.84 NR3C1 (0.71) NR3C1PGRNR1I2MLNRADORA3
Meprednisone SCHEMBL9746961 0.84 HSD17B10 (0.66) NR3C1PGRNR1I2HSD17B10HIF1A
Meprednisone SCHEMBL10532955 0.83 PGR (0.68) NR3C1PGRNR1I2HSD17B10HIF1A
Cloprednol SCHEMBL4886 0.83 PGR (1.00) NR3C1PGRNR1I2MLNRADORA3
Cloprednol SCHEMBL19327143 0.83 PGR (1.00) NR3C1PGRNR1I2MLNRADORA3
Cloprednol SCHEMBL11209368 0.83 PGR (1.00) NR3C1PGRNR1I2MLNRADORA3
Paramethasone SCHEMBL4471853 0.82 PGR (0.68) NR3C1PGRNR1I2HSD17B10HIF1A
Meprednisone SCHEMBL5483442 0.81 HSD17B10 (0.70) NR3C1PGRNR1I2HSD17B10HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2699572-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
EP-2699579-A1 PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS Origenis GmbH (DE) 2014-02-26 — — EP disclosed
WO-2012143143-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed
WO-2012143144-A1 PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS ORIGENIS GMBH (DE) 2012-10-26 — — WO disclosed