Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NOS3 | P29474 | 3/20 | 0.48 |
| ▸ | NOS2 | P35228 | 3/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.43 |
| ▸ | GCK | P35557 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27673210 | 0.75 | KDM4E (0.52) | ALDH1A1NOS3NOS2GCKCA2 | |
| SCHEMBL27496175 | 0.75 | NOS3 (0.48) | NOS3NOS2HRH4NOS1KDM4E | |
| SCHEMBL1457195 | 0.71 | ALDH1A1 (1.00) | ALDH1A1LMNACA2POLBKDM4E | |
| SCHEMBL30370886 | 0.71 | ALDH1A1 (1.00) | ALDH1A1LMNACA2POLBKDM4E | |
| SCHEMBL5252690 | 0.70 | NOS3 (0.40) | NOS3NOS2GCKLMNANOS1 | |
| SCHEMBL686828 | 0.69 | LMNA (0.61) | ALDH1A1LMNACA2POLB | |
| SCHEMBL8519013 | 0.69 | ALDH1A1 (0.57) | ALDH1A1LMNACA2POLBMEN1 | |
| SCHEMBL25887348 | 0.68 | CA2 (0.47) | ALDH1A1NOS3NOS2HRH4LMNA | |
| SCHEMBL1334378 | 0.67 | ALDH1A1 (0.54) | ALDH1A1LMNACA2POLBMEN1 | |
| SCHEMBL6036994 | 0.67 | ALDH1A1 (0.55) | ALDH1A1LMNACA2POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2707357-A1 | PYRIDYL AMINOPYRIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2704571-A1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-03-12 | — | — | EP | disclosed |
| WO-2012154520-A1 | PYRIDYL AMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-15 | — | — | WO | disclosed |
| WO-2012151137-A1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-11-08 | — | — | WO | disclosed |