SCHEMBL686828

SCHEMBL686828

Nc1cccc(S(=O)(=O)C(F)(F)F)c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.61
CA2 P00918 4/20 0.59
CA12 O43570 3/20 0.59
CA1 P00915 3/20 0.59
CA9 Q16790 3/20 0.59
CA4 P22748 2/20 0.59
CA14 Q9ULX7 1/20 0.59
ALDH1A1 P00352 2/20 0.58
TSHR P16473 2/20 0.57
HSD17B10 Q99714 1/20 0.57
TDP1 Q9NUW8 1/20 0.57
F2 P00734 3/20 0.49
PRSS1 P07477 3/20 0.49
PRSS2 P07478 3/20 0.49
PRSS3 P35030 3/20 0.49
POLB P06746 1/20 0.47
MAPK1 P28482 1/20 0.45
CYP19A1 P11511 1/20 0.45
PKM P14618 2/20 0.44
HTR6 P50406 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8519013 0.85 ALDH1A1 (0.57) LMNACA2CA1ALDH1A1POLB
SCHEMBL11237563 0.85 LMNA (0.57) LMNACA2CA12CA1CA9
SCHEMBL22962967 0.82 LMNA (0.53) LMNACA2CA12CA1CA9
SCHEMBL10505835 0.80 LMNA (0.52) LMNACA2CA12CA1CA9
SCHEMBL12325544 0.80 LMNA (0.61) LMNACA2CA12CA1CA9
SCHEMBL9951665 0.80 CA2 (0.68) CA2CA12CA1CA9CA4
SCHEMBL2477062 0.79 CA2 (0.53) LMNACA2CA12CA1CA9
SCHEMBL6036994 0.79 ALDH1A1 (0.55) LMNACA2CA12CA1CA9
Hydrochloric Acid SCHEMBL3175332 0.78 CA2 (0.51) LMNACA2CA12CA1CA9
SCHEMBL1272213 0.78 ALDH1A1 (0.50) CA2CA12CA1CA9ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 193 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118421149-A Corrosion-resistant acrylic basalt finish paint and preparation method thereof 北京初岩新材料科技有限公司 2024-08-02 CN claimed
CN-104531397-A Cleaning solution for sheet glass substrate thinning pre-cleaning, and application thereof HUIJING DISPLAY TECHNOLOGY SUZHOU CO LTD 2015-04-22 CN claimed
US-20100041657-A1 HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES NOVO NORDICK A/S (DK) 2010-02-18 US claimed
EP-1451160-B1 PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN ICAGEN INC (US) 2010-01-13 EP claimed
EP-1881961-A1 NEW HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES NOVO NORDISK A/S (DK) 2008-01-30 EP claimed
EP-1761541-B1 PYRRAZOLO-PYRIMIDINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2008-01-09 EP claimed
EP-1761541-A1 PYRRAZOLO-PYRIMIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2007-03-14 EP claimed
WO-2006120178-A1 NEW HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES NOVO NORDISK A/S (DK) 2006-11-16 WO claimed
WO-2005123738-A1 PYRRAZOLO-PYRIMIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2005-12-29 WO claimed
US-4767757-A Acyloxythiophene-carboxamide fungicides, compositions and use BAYER AKTIENGESELLSCHAFT (DE) 1988-08-30 US claimed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP claimed
US-20260001861-A1 PYRIDINE CARBOXAMIDE COMPOUNDS FOR INHIBITING NAV1.8 LIEBER INST INC (US) 2026-01-01 US disclosed
US-20250221966-A1 RXFP1 AGONISTS BRISTOL MYERS SQUIBB CO (US) 2025-07-10 US disclosed
US-12234221-B2 Pyridine carboxamide compounds for inhibiting NAV1.8 LIEBER INSTITUTE, INC. (US) 2025-02-25 US disclosed
US-20240317727-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER DUKE UNIVERSITY 2024-09-26 US disclosed
EP-0241735-A2 Acyloxythiophene carbon amide BAYER AG (DE) 1987-10-21 EP disclosed
EP-0119449-A1 Aminopyrazoline derivatives THE WELLCOME FOUNDATION LIMITED (GB) 1984-09-26 EP disclosed
US-4348411-A Combating bacteria with halogenomethylsulphonylphenyl-phthalamic acids BAYER AKTIENGESELLSCHAFT (DE) 1982-09-07 US disclosed
EP-0043487-A1 Halogenmethylsulfonylphenyl-phthalamide acids, process for their preparation and their bactericidal use BAYER AG (DE) 1982-01-13 EP disclosed
US-4267328-A USEFUL AS ANALGESICS OR PSYCHOTROPIC AGENTS SYNTHELABO (FR) 1981-05-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250221966-A1 RXFP1 AGONISTS RXFP1, RXFP2, RXFP3 LMNA 3685/4885CA2 3556/4885CA12 4434/4885
US-20100041657-A1 HALOALKYLSULFONE SUBSTITUTED COMPOUNDS USEFUL FOR TREATING OBESITY AND DIABETES RPS12, GPR119, ATP12A LMNA 4278/4885CA2 1139/4885CA12 1128/4885
US-12234221-B2 Pyridine carboxamide compounds for inhibiting NAV1.8 SCN8A, SCN1A, SCN2A LMNA 1580/4885CA2 613/4885CA12 3752/4885
US-20260001861-A1 PYRIDINE CARBOXAMIDE COMPOUNDS FOR INHIBITING NAV1.8 SCN8A, SCN1A, SCN1B LMNA 916/4885CA2 165/4885CA12 2568/4885
US-20240317727-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER HSF1, HSP90AB1, HSP90AA1 LMNA 1978/4885CA2 2575/4885CA12 3249/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.