SCHEMBL1374723

SCHEMBL1374723

C=CS(=O)(=O)c1ccc([NH])cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.59
MAPT P10636 3/20 0.59
LMNA P02545 2/20 0.59
NPC1 O15118 2/20 0.59
TP53 P04637 2/20 0.59
MAPK1 P28482 2/20 0.59
RAB9A P51151 2/20 0.59
HSD17B10 Q99714 2/20 0.59
TSHR P16473 2/20 0.59
XBP1 P17861 1/20 0.59
HTT P42858 1/20 0.59
MDM2 Q00987 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
TDP1 Q9NUW8 3/20 0.40
TLR9 Q9NR96 2/20 0.38
POLB P06746 1/20 0.32
EPAS1 Q99814 1/20 0.32
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
CA9 Q16790 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10860893 0.87 ALDH1A1 (0.73) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL30697854 0.76 ALDH1A1 (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL4294100 0.76 ALDH1A1 (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL11290078 0.76 ALDH1A1 (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL7150046 0.76 LMNA (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL23320335 0.76 LMNA (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL1374724 0.76 TSHR (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL4300190 0.76 ALDH1A1 (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL7148940 0.76 NPC1 (0.59) ALDH1A1MAPTLMNANPC1TP53
SCHEMBL2889896 0.76 TLR9 (0.67) ALDH1A1MAPTLMNANPC1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1490441-B2 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DYSTAR COLOURS DISTRIB GMBH (DE) 2012-12-26 EP claimed
US-20090320217-A1 MIXTURES OF FIBRE-REACTIVE AZO DYES DYSTAR TEXTIFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-12-31 US claimed
EP-2118214-A2 MIXTURES OF FIBRE-REACTIVE AZO DYES DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2009-11-18 EP claimed
US-20090025152-A1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PREPARATION AND USE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2009-01-29 US claimed
EP-1508596-B1 Mixtures of azo reactive dyes, process for their preparation and the use thereof DYSTAR TEXTILFARBEN GMBH & CO (DE) 2009-01-28 EP claimed
EP-1490441-B1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-09-10 EP claimed
WO-2008095802-A2 MIXTURES OF FIBRE-REACTIVE AZO DYES DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2008-08-14 WO claimed
EP-1490442-B1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-03-19 EP claimed
EP-1508598-B1 Mixture of fiberreactive azo dyes process for their preparation and use DYSTAR TEXTILFARBEN GMBH & CO (DE) 2008-03-19 EP claimed
US-7132515-B2 Fiber-reactive AZO dyes, preparation thereof and use thereof DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2006-11-07 US claimed
US-20050034252-A1 Dye mixtures of fiber-reactive azo dyes, their preparation and their use DYSTAR TEXTILFARBEN GMBH & CO. (DE) 2005-02-17 US claimed
EP-1499681-A1 FIBRE-REACTIVE AZO DYES, THEIR PRODUCTION AND THEIR USE DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2005-01-26 EP claimed
EP-1490441-A1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2004-12-29 EP claimed
EP-1490442-A1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DyStar Textilfarben GmbH & Co. Deutschland KG (DE) 2004-12-29 EP claimed
WO-2003089521-A1 FIBRE-REACTIVE AZO DYES, THEIR PRODUCTION AND THEIR USE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2003-10-30 WO claimed
WO-2003080739-A1 DYE MIXTURES OF FIBER-REACTIVE AZO DYES, THEIR PRODUCTION AND USE DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2003-10-02 WO claimed
WO-2003080741-A1 DYE MIXTURES OF FIBRE REACTIVE AZODYES, PRODUCTION AND USE THEREOF DYSTAR TEXTILFARBEN GMBH & CO. DEUTSCHLAND KG (DE) 2003-10-02 WO claimed
EP-0739950-B1 Reactive dioxazine dye stuffs, their preparation and use CIBA SC HOLDING AG (CH) 2002-09-18 EP claimed
US-5772698-A Reactive dyes from the dioxazine series, their preparation and use CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-06-30 US claimed
EP-0739950-A2 Reactive dioxazine dye stuffs, their preparation and use CIBA-GEIGY AG (CH) 1996-10-30 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050034252-A1 Dye mixtures of fiber-reactive azo dyes, their preparation and their use CRY1, FZD7, CBR3 ALDH1A1 617/4885MAPT 3415/4885LMNA 1296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.