Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.30 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15487989 | 0.91 | CYP11B1 (0.40) | ENPP2CYP11B1CYP11B2SIRT2CCR1 | |
| SCHEMBL31645949 | 0.80 | ENPP2 (0.35) | ENPP2CYP11B1CYP11B2SIRT2 | |
| SCHEMBL31646062 | 0.77 | ENPP2 (0.34) | ENPP2CYP11B1CYP11B2SIRT2 | |
| SCHEMBL1371991 | 0.75 | IDO1 (0.36) | HSD11B1ENPP2CYP11B1CYP11B2SIRT2 | |
| SCHEMBL1373514 | 0.74 | ENPP2 (0.39) | HSD11B1ENPP2CYP11B1CYP11B2SIRT2 | |
| SCHEMBL7784539 | 0.74 | CYP11B1 (0.40) | ENPP2CYP11B1CYP11B2SIRT2OPRM1 | |
| SCHEMBL7786406 | 0.74 | CYP11B1 (0.40) | ENPP2CYP11B1CYP11B2SIRT2OPRM1 | |
| SCHEMBL7787709 | 0.73 | CYP11B1 (0.37) | HSD11B1ENPP2CYP11B1CYP11B2SIRT2 | |
| SCHEMBL7786397 | 0.72 | CYP11B1 (0.39) | ENPP2CYP11B1CYP11B2SIRT2OPRM1 | |
| SCHEMBL8608329 | 0.72 | CYP11B1 (0.39) | ENPP2CYP11B1CYP11B2SIRT2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464075-B2 | Influenza A virus inhibition | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-10-11 | — | — | US | disclosed |
| US-9464075-B2 | Influenza A virus inhibition | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-10-11 | — | — | US | disclosed |
| US-9453005-B2 | Inhibition of influenza M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453005-B2 | Inhibition of influenza M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-09-27 | — | — | US | disclosed |
| US-9453005-B2 | Inhibition of influenza M2 proton channel | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-09-27 | — | — | US | disclosed |
| US-20110294785-A1 | INFLUENZA A VIRUS INHIBITION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110294785-A1 | INFLUENZA A VIRUS INHIBITION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-12-01 | — | — | US | disclosed |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2011-11-24 | — | — | US | disclosed |
| WO-2010033339-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2010033340-A1 | INFLUENZA A VIRUS INHIBITION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2010033339-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294785-A1 | INFLUENZA A VIRUS INHIBITION | HAVCR2, MAVS, CD4 | HSD11B1 3761/4885ENPP2 1101/4885CYP11B1 3740/4885 |
| US-20110288111-A1 | INHIBITION OF INFLUENZA M2 PROTON CHANNEL | HVCN1, TRPM2, ASIC1 | HSD11B1 4500/4885ENPP2 945/4885CYP11B1 3951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.