Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7686431 | 0.95 | BACE1 (0.56) | HRH3BACE1KDM4EL3MBTL1KCNH2 | |
| SCHEMBL1377693 | 0.94 | LTA4H (0.55) | HRH3BACE1KDM4ELTA4HALDH1A1 | |
| SCHEMBL1376598 | 0.88 | DRD2 (0.47) | HRH3 | |
| SCHEMBL1377207 | 0.88 | DRD3 (0.53) | HRH3TSHRHRH1 | |
| SCHEMBL7632638 | 0.85 | L3MBTL1 (0.47) | L3MBTL1HRH1 | |
| SCHEMBL1379788 | 0.84 | DRD2 (0.45) | — | |
| SCHEMBL7638803 | 0.82 | CYP1A2 (0.38) | KDM4E | |
| SCHEMBL7631973 | 0.82 | MAOA (0.38) | KDM4E | |
| SCHEMBL7633768 | 0.80 | MAOA (0.37) | KDM4E | |
| SCHEMBL1376907 | 0.80 | HTR7 (0.40) | HRH3BACE1KDM4EKCNH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216249-A2 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019832-A2 | THIENOISOXAZOLE PHENOXY UNSUBSTITUTED ETHYL AND PROPYL DERIVATIVES USEFUL AS D4 ANTAGONISTS | AVENTIS PHARMACEUTICALS, INC. (US) | 2001-03-22 | — | — | WO | disclosed |