Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 2/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | RHEB | Q15382 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27203390 | 0.88 | CACNA1G (0.49) | CACNA1HCACNA1GGAAHTTPRKAG1 | |
| SCHEMBL29770413 | 0.88 | CACNA1G (0.49) | CACNA1HCACNA1GGAAHTTPRKAG1 | |
| SCHEMBL4490880 | 0.78 | PDGFRB (0.58) | PIM1PDGFRBFGFR1KDR | |
| SCHEMBL8353209 | 0.76 | ALDH1A1 (0.59) | PIM1JAK2JAK1CCNE1CDK2 | |
| SCHEMBL27241025 | 0.73 | GAA (0.57) | CACNA1HCACNA1GGAAHTTRHEB | |
| SCHEMBL7208984 | 0.72 | RIPK1 (0.58) | CACNA1HCACNA1GGAAHTTRHEB | |
| Hydrochloric Acid SCHEMBL4506067 | 0.72 | PDGFRB (0.42) | PIM1PRMT5WDR77FLT3KCNH2 | |
| SCHEMBL5407734 | 0.71 | NPY5R (0.50) | CACNA1HCACNA1GGAAHTTRHEB | |
| SCHEMBL4504235 | 0.70 | PTGER4 (0.49) | PIM1GAAHTTPIM3BRD4 | |
| SCHEMBL3699142 | 0.70 | CYP1A2 (0.43) | PIM1PIM2CCNT1CDK9KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667679-B1 | AMINOBENZIMIDAZOLES AS SELECTIVE MELANIN CONCENTRATING HORMONE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS | SCHERING CORP (US) | 2009-06-03 | — | — | EP | disclosed |