Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22781556 | 0.77 | MAP4K4 (0.40) | MAP4K4ALDH1A1HSD17B10LMNAMAPT | |
| SCHEMBL19522683 | 0.74 | ACHE (0.39) | ALDH1A1LMNAMAPTSMN1; SMN2TSHR | |
| SCHEMBL14392198 | 0.71 | ALDH1A1 (0.34) | ALDH1A1LMNATDP1TSHR | |
| SCHEMBL21912591 | 0.70 | ACHE (0.39) | HSD17B10MAPTTP53NPC1RAB9A | |
| SCHEMBL9973786 | 0.69 | PDE2A (0.36) | ALDH1A1HSD17B10LMNAMAPTCYP2C9 | |
| SCHEMBL59217 | 0.69 | — | — | |
| SCHEMBL12849546 | 0.68 | KDM1A (0.37) | — | |
| SCHEMBL13825284 | 0.67 | NPC1 (0.51) | ALDH1A1HSD17B10MAPTNPC1RAB9A | |
| SCHEMBL112382 | 0.67 | — | — | |
| SCHEMBL8181149 | 0.67 | TDP1 (0.55) | MAP4K4ALDH1A1HSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765788-B1 | 3-AMINOINDAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SGK-ASSOCIATED DISEASES | MERCK PATENT GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |