Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 6/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3623702 | 0.95 | SLC40A1 (0.58) | SLC40A1HTR6CKS1BSKP2HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL1380515 | 0.87 | RAD52 (0.43) | SLC40A1RAD52UBE2NL3MBTL1MEN1 | |
| Trifluoroacetic Acid SCHEMBL1379813 | 0.85 | HTR6 (0.47) | HTR6MEN1GAAKMT2A | |
| Trifluoroacetic Acid SCHEMBL1380631 | 0.85 | HTR6 (0.45) | SLC40A1HTR6HSD11B1RAD52UBE2N | |
| SCHEMBL7045097 | 0.84 | SLC40A1 (0.49) | SLC40A1HTR6PRKD1 | |
| Trifluoroacetic Acid SCHEMBL6047104 | 0.82 | SLC40A1 (0.47) | SLC40A1HTR6HSD11B1RAD52UBE2N | |
| Trifluoroacetic Acid SCHEMBL1380171 | 0.80 | L3MBTL1 (0.43) | HTR6RAD52UBE2NL3MBTL1PRKD1 | |
| SCHEMBL1379328 | 0.78 | TDP1 (0.50) | SLC40A1HTR6CKS1BSKP2L3MBTL1 | |
| SCHEMBL3616470 | 0.78 | MEN1 (0.50) | SLC40A1HTR6L3MBTL1MEN1KMT2A | |
| SCHEMBL1381623 | 0.77 | HTR6 (0.41) | SLC40A1HTR6HSD11B1RAD52UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4731114-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |
| US-7144883-B2 | Bicyclic sulfonamide compounds | BIOVITRUM AB (SE) | 2006-12-05 | — | — | US | disclosed |