Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380517 | 0.87 | L3MBTL1 (0.37) | HTR6HSD11B1SCN9AHTR2AHTR7 | |
| SCHEMBL1379816 | 0.86 | ALDH1A1 (0.37) | HTR6SCN9ATP53HTR7RAD52 | |
| SCHEMBL1380633 | 0.85 | HSD11B1 (0.41) | HTR6HSD11B1MAPTHTR2AHTR7 | |
| SCHEMBL1380174 | 0.80 | RAD52 (0.36) | HTR6HTR2AHTR7HTR1ADRD2 | |
| Trifluoroacetic Acid SCHEMBL1381621 | 0.77 | SLC40A1 (0.52) | HTR6HSD11B1SLC40A1RAD52UBE2N | |
| SCHEMBL3623702 | 0.76 | SLC40A1 (0.58) | HTR6HSD11B1SCN9ASLC40A1EPHX2 | |
| SCHEMBL3563289 | 0.67 | HTR6 (0.75) | HTR6MAPTHTR2AHTR7HTR1A | |
| Trifluoroacetic Acid SCHEMBL1380515 | 0.66 | RAD52 (0.43) | SLC40A1EPHX2RAD52UBE2NL3MBTL1 | |
| Hydrochloric Acid SCHEMBL2195292 | 0.66 | HTR6 (0.74) | HTR6MAPTHTR2AHTR7HTR1A | |
| SCHEMBL3625132 | 0.66 | HTR6 (0.51) | HTR6HSD11B1HTR7HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4731114-B2 | — | — | 2011-07-20 | — | — | JP | claimed |
| EP-1412325-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2004-04-28 | — | — | EP | claimed |
| WO-2002100822-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS, PROCESS FOR THEIR USE AS MEDICAMENT FOR THE TREATMENT OF CNS DISORDERS, OBESITY AND TYPE II DIABETES | BIOVITRUM AB (SE) | 2002-12-19 | — | — | WO | claimed |