Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NMUR2 | Q9GZQ4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21556992 | 0.84 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CTSHRCYP3A4 | |
| SCHEMBL22826941 | 0.82 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CTSHRHIF1A | |
| SCHEMBL20852478 | 0.82 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CTSHRHIF1A | |
| SCHEMBL19361305 | 0.82 | ADRA2A (0.41) | ADRA2AADRA2BADRA2CTSHRHIF1A | |
| SCHEMBL13840702 | 0.80 | BCAT2 (0.40) | ADRA2AADRA2BADRA2CTSHRCYP3A4 | |
| SCHEMBL13840703 | 0.76 | MAPT (0.47) | ADRA2AADRA2BADRA2CTSHRCYP3A4 | |
| SCHEMBL14769097 | 0.72 | HIF1A (0.61) | ADRA2AADRA2BADRA2CTSHRHIF1A | |
| SCHEMBL20852549 | 0.72 | HIF1A (0.61) | ADRA2AADRA2BADRA2CTSHRHIF1A | |
| SCHEMBL13840700 | 0.71 | ADRB2 (0.46) | TSHRCYP3A4HIF1ABLMKDM4E | |
| SCHEMBL21556875 | 0.70 | BCAT2 (0.38) | ADRA2AADRA2BADRA2CTSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190658-A1 | IMAGING AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-07-06 | — | — | US | disclosed |
| US-20150246142-A1 | IMAGING AGENTS | UNIV MICHIGAN (US) | 2015-09-03 | — | — | US | disclosed |
| US-7534418-B2 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-19 | — | — | US | disclosed |
| US-7534418-B2 | Imaging agents | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2009-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246142-A1 | IMAGING AGENTS | SLC18A1, VHL, GDI1 | ADRA2A 153/4885ADRA2B 202/4885ADRA2C 270/4885 |
| US-20170190658-A1 | IMAGING AGENTS | SLC18A1, VHL, GDI1 | ADRA2A 153/4885ADRA2B 202/4885ADRA2C 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.