Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 5/20 | 0.59 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2358001 | 0.87 | NR3C2 (0.60) | NR3C2TRPV1AVPR2GPR27MAOA | |
| SCHEMBL2541697 | 0.86 | NR3C2 (0.54) | NR3C2AVPR2GPR27LMNAALDH1A1 | |
| SCHEMBL30038582 | 0.85 | CFTR (0.46) | NR3C2PTPRCTRPV1PTGES | |
| SCHEMBL27941141 | 0.82 | LMNA (0.43) | NR3C2PTPRCTRPV1LMNAMAPT | |
| SCHEMBL2439584 | 0.79 | NR3C2 (0.79) | NR3C2PTPRCAVPR2GPR27MAOA | |
| SCHEMBL1384488 | 0.78 | AVPR2 (0.45) | AVPR2GPR27MAOAMAOBMT-CO2 | |
| SCHEMBL17363955 | 0.78 | NR3C2 (0.51) | NR3C2PTPRCAVPR2GPR27MAOA | |
| SCHEMBL1382627 | 0.78 | NR3C2 (0.48) | NR3C2AVPR2GPR27MAOAMAOB | |
| SCHEMBL1384216 | 0.78 | NR3C2 (0.55) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL28064850 | 0.77 | NR3C2 (0.45) | NR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | claimed |
| JP-4703649-B2 | — | — | 2011-06-15 | — | — | JP | claimed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | claimed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | claimed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | claimed |
| US-20240239746-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-07-18 | — | — | US | disclosed |
| US-20240239746-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2024-07-18 | — | — | US | disclosed |
| EP-1773768-B1 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2018-08-22 | — | — | EP | disclosed |
| CN-102186817-B | Atropisomers of (hydroxyalkyl) pyrrole derivatives | 埃克塞利希斯股份有限公司 | 2017-05-17 | — | — | CN | disclosed |
| EP-2349997-B1 | ATROPISOMERS OF (HYDROXYALKYL) PYRROLE DERIVATIVES | EXELIXIS INC (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8754118-B2 | Atropisomer of pyrrole derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-06-17 | — | — | US | disclosed |
| US-20140024696-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2014-01-23 | — | — | US | disclosed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | EXELIXIS, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| EP-1773768-A4 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS INC (US) | 2008-08-06 | — | — | EP | disclosed |
| EP-1773768-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
| WO-2006012642-A2 | PYRROLE DERIVATIVES AS PHARMACEUTICAL AGENTS | EXELIXIS, INC. (US) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234270-A1 | Pyrrole Derivatives As Pharmaceutical Agents | PRLHR, PTGDR, TACR1 | NR3C2 119/4885PTPRC 452/4885TRPV1 22/4885 |
| US-20140024696-A1 | ATROPISOMER OF PYRROLE DERIVATIVE | CYP11B2, CYP11B1, PYCR1 | NR3C2 13/4885PTPRC 2525/4885TRPV1 1854/4885 |
| US-20240239746-A1 | PREPARATION METHOD FOR PYRROLE AMIDE COMPOUND | HPGDS, HRH4, FAAH | NR3C2 1528/4885PTPRC 4756/4885TRPV1 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.