Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 10/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CFD | P00746 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL44645 | 0.89 | WDR5 (0.51) | WDR5POLB | |
| SCHEMBL45795 | 0.85 | CHRM3 (0.49) | WDR5TP53CHRM3 | |
| SCHEMBL44675 | 0.85 | ALDH1A1 (0.53) | WDR5 | |
| SCHEMBL44398 | 0.83 | CHRM3 (0.52) | WDR5TP53CHRM3 | |
| SCHEMBL44862 | 0.82 | GAA (0.47) | WDR5TP53POLBRAB9A | |
| SCHEMBL45277 | 0.80 | TP53 (0.49) | WDR5TP53POLBRAB9A | |
| SCHEMBL44495 | 0.79 | WDR5 (0.55) | WDR5POLB | |
| SCHEMBL38543 | 0.79 | WDR5 (0.45) | WDR5AURKAPOLBRAB9APSEN1 | |
| SCHEMBL44054 | 0.78 | MAPT (0.53) | TP53 | |
| SCHEMBL44636 | 0.76 | TP53 (0.43) | WDR5TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009059162-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-07 | — | — | WO | disclosed |