Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | WDR5 | P61964 | 3/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844857 | 0.85 | WDR5 (0.51) | WDR5 | |
| SCHEMBL44645 | 0.85 | WDR5 (0.51) | MAPTLMNAHPGDMEN1KMT2A | |
| SCHEMBL45795 | 0.82 | CHRM3 (0.49) | MAPTLMNAGAAKDM4EWDR5 | |
| SCHEMBL44398 | 0.80 | CHRM3 (0.52) | WDR5 | |
| SCHEMBL44862 | 0.79 | GAA (0.47) | ALDH1A1MAPTLMNAHPGDGAA | |
| SCHEMBL44653 | 0.78 | ALDH1A1 (0.54) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL45277 | 0.77 | TP53 (0.49) | ALDH1A1MAPTLMNAHPGDMEN1 | |
| SCHEMBL44495 | 0.76 | WDR5 (0.55) | ALDH1A1MAPTHPGDMEN1KMT2A | |
| SCHEMBL38543 | 0.76 | WDR5 (0.45) | MAPTHPGDGAAWDR5CYP1A2 | |
| SCHEMBL44054 | 0.76 | MAPT (0.53) | MAPTLMNAKMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | claimed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |