Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4964440 | 0.88 | ALDH1A1 (0.50) | EGFRPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL4963765 | 0.85 | POLB (0.48) | EGFRPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL13869738 | 0.81 | POLB (0.56) | POLBHSD17B10ALDH1A1MEN1GAA | |
| SCHEMBL13869757 | 0.81 | MAPK1 (0.60) | EGFRPOLBHSD17B10ALDH1A1KDM4E | |
| SCHEMBL13869741 | 0.80 | POLB (0.57) | EGFRPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL4962386 | 0.80 | TRPM8 (0.58) | EGFRHSD17B10ALDH1A1TSHRKDM4E | |
| SCHEMBL9658985 | 0.79 | HSD17B10 (0.72) | EGFRPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL6380511 | 0.78 | PTGS2 (0.56) | EGFRPOLBHSD17B10ALDH1A1TSHR | |
| SCHEMBL14518119 | 0.76 | MAPT (0.61) | POLBALDH1A1KDM4EL3MBTL1MAPT | |
| SCHEMBL12687870 | 0.75 | ALDH1A1 (0.59) | POLBALDH1A1KDM4EL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521461-B2 | Benzoic acid derivatives as modulators of PPAR alpha and gamma | ASTRAZENECA AB (SE) | 2009-04-21 | — | — | US | disclosed |
| US-7521461-B2 | Benzoic acid derivatives as modulators of PPAR alpha and gamma | ASTRAZENECA AB (SE) | 2009-04-21 | — | — | US | disclosed |