Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 12/20 | 0.45 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.44 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387945 | 0.89 | FOLH1 (0.55) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL1387643 | 0.89 | FOLH1 (0.55) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL1387645 | 0.89 | FOLH1 (0.55) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL7447157 | 0.80 | FOLH1 (0.51) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL16124669 | 0.79 | NOD1 (0.51) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL16124659 | 0.78 | NOD1 (0.53) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL9828838 | 0.78 | NOD1 (0.49) | FOLH1 | |
| SCHEMBL10036530 | 0.78 | NOD1 (0.53) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL14570048 | 0.76 | FOLH1 (0.53) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL9830451 | 0.75 | NOD1 (0.47) | FOLH1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-H09507236-A | — | — | 1997-07-22 | — | — | JP | claimed |
| EP-0737197-A1 | AMINO ALKANOIC ESTERS OF RAPAMYCIN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-10-16 | — | — | EP | claimed |
| WO-1995018133-A1 | AMINO ALKANOIC ESTERS OF RAPAMYCIN | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-07-06 | — | — | WO | claimed |
| US-5389639-A | Immunosuppressants | AMERICAN HOME PRODUCTS COMPANY (US) | 1995-02-14 | — | — | US | disclosed |