Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387543 | 1.00 | ALDH1A1 (0.44) | ALDH1A1ALDH2CYP19A1TDP1L3MBTL1 | |
| SCHEMBL1387541 | 1.00 | ALDH1A1 (0.44) | ALDH1A1ALDH2CYP19A1TDP1L3MBTL1 | |
| SCHEMBL8399414 | 0.84 | ALDH1A1 (0.44) | ALDH1A1ALDH2CYP19A1TDP1L3MBTL1 | |
| SCHEMBL8486117 | 0.83 | SIGMAR1 (0.44) | ALDH1A1TDP1DDB1CRBNTHRB | |
| SCHEMBL29141201 | 0.79 | BRD4 (0.48) | ALDH1A1ALDH2TDP1L3MBTL1GAA | |
| SCHEMBL8398575 | 0.76 | THRB (0.42) | ALDH1A1ALDH2TDP1L3MBTL1SLC6A2 | |
| SCHEMBL8399014 | 0.76 | DDB1 (0.55) | ALDH1A1ALDH2CYP19A1TDP1L3MBTL1 | |
| SCHEMBL8919347 | 0.74 | MEN1 (0.44) | ALDH1A1ALDH2CYP19A1SLC6A2SLC6A4 | |
| SCHEMBL8489760 | 0.73 | CCKBR (0.46) | ALDH1A1ALDH2TDP1L3MBTL1GAA | |
| SCHEMBL8488193 | 0.73 | ALDH1A1 (0.36) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5977355-A | Processes and intermediates for preparing 3-amino-benzo(b)azepinones | PFIZER INC. (US) | 1999-11-02 | — | — | US | claimed |
| JP-H09512033-A | — | — | 1997-12-02 | — | — | JP | claimed |
| EP-0785925-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 3-AMINO-BENZO(B)AZEPINONES | PFIZER INC. (US) | 1997-07-30 | — | — | EP | claimed |
| WO-1996010564-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 3-AMINO-BENZO(B)AZEPINONES | PFIZER INC. (US) | 1996-04-11 | — | — | WO | claimed |
| US-5977355-A | Processes and intermediates for preparing 3-amino-benzo(b)azepinones | PFIZER INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0785925-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 3-AMINO-BENZO(B)AZEPINONES | PFIZER INC. (US) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996010564-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 3-AMINO-BENZO(B)AZEPINONES | PFIZER INC. (US) | 1996-04-11 | — | — | WO | disclosed |