SCHEMBL1388942

SCHEMBL1388942

CCCOC(=O)c1cc2c3c(ccc2cc1O)OC(c1ccccc1)(c1ccccc1)C=C3

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.39
KDM4E B2RXH2 3/20 0.38
L3MBTL1 Q9Y468 3/20 0.37
LMNA P02545 1/20 0.36
MAOB P27338 2/20 0.35
HSD17B10 Q99714 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34
PTPN1 P18031 2/20 0.34
MYC P01106 1/20 0.34
MAPT P10636 3/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
HIF1A Q16665 1/20 0.32
HSP90AA1 P07900 1/20 0.32
TP53 P04637 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29565402 1.00 ALDH1A1 (0.39) ALDH1A1KDM4EL3MBTL1LMNAMAOB
SCHEMBL8816487 0.89 ALDH1A1 (0.38) ALDH1A1KDM4ELMNAMAOBHSD17B10
SCHEMBL5648658 0.84 HIF1A (0.33) ALDH1A1KDM4EL3MBTL1SMN1; SMN2MAPT
SCHEMBL1387201 0.76 POLB (0.40) ALDH1A1KDM4EPTPN1MAPTKMT2A
SCHEMBL1387324 0.76 HIF1A (0.35) ALDH1A1KDM4EL3MBTL1LMNAHSD17B10
SCHEMBL30819545 0.76 ALDH1A1 (0.39) ALDH1A1KDM4EL3MBTL1MAOBHSD17B10
SCHEMBL13061587 0.74 ALOX5 (0.43) ALDH1A1KDM4EL3MBTL1LMNASMN1; SMN2
SCHEMBL361912 0.73 LCK (0.45) ALDH1A1KDM4EL3MBTL1SMN1; SMN2PTPN1
SCHEMBL6384117 0.73 ALDH1A1 (0.40) ALDH1A1KDM4EL3MBTL1LMNAMAOB
SCHEMBL5647665 0.72 KMT2A (0.35) ALDH1A1KDM4EMAPTKMT2AHIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US claimed
EP-4313567-B1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC (CH) 2025-01-29 EP claimed
US-12111443-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-10-08 US claimed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US claimed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN claimed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP claimed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP claimed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
EP-4304842-A1 METHOD FOR MAKING PHOTOFUNCTIONAL CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US claimed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US claimed
US-7166357-B2 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL, INC. (US) 2007-01-23 US claimed
US-20040185268-A1 Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation TRANSITIONS OPTICAL LIMITED (IE) 2004-09-23 US claimed
EP-0710367-B1 PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS PPG IND OHIO INC (US) 2000-08-30 EP claimed
JP-H09505271-A 1997-05-27 JP claimed
EP-0710367-A4 1996-05-15 EP claimed
EP-0710367-A1 PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS PPG INDUSTRIES, INC. (US) 1996-05-08 EP claimed
US-5466398-A Photochromic substituted naphthopyran compounds TRANSITIONS OPTICAL, INC. (US) 1995-11-14 US claimed
WO-1995000867-A1 PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS PPG INDUSTRIES, INC. (US) 1995-01-05 WO claimed