Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5646001 | 0.87 | MAPT (0.36) | POLBALDH1A1HPGDKDM4EHIF1A | |
| SCHEMBL8816487 | 0.86 | ALDH1A1 (0.38) | POLBALDH1A1HPGDKDM4EHIF1A | |
| SCHEMBL7595691 | 0.81 | HIF1A (0.34) | POLBALDH1A1HPGDKDM4EHIF1A | |
| SCHEMBL1334167 | 0.79 | PLA2G2A (0.35) | ALDH1A1HPGDKDM4EHIF1AKMT2A | |
| SCHEMBL1387468 | 0.78 | HIF1A (0.36) | ALDH1A1KDM4EHIF1AKMT2AMEN1 | |
| SCHEMBL13061587 | 0.77 | ALOX5 (0.43) | ALDH1A1HPGDKDM4EKMT2AMAPT | |
| SCHEMBL7131287 | 0.76 | KDM4E (0.40) | POLBALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL7128812 | 0.76 | MAPT (0.40) | POLBALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL361912 | 0.76 | LCK (0.45) | ALDH1A1HPGDKDM4EMAPTPTPN1 | |
| SCHEMBL1388942 | 0.76 | ALDH1A1 (0.39) | ALDH1A1KDM4EHIF1AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166357-B2 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL, INC. (US) | 2007-01-23 | — | — | US | claimed |
| US-20040185268-A1 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | claimed |
| EP-0710367-B1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2000-08-30 | — | — | EP | claimed |
| JP-H09505271-A | — | — | 1997-05-27 | — | — | JP | claimed |
| EP-0710367-A4 | — | — | 1996-05-15 | — | — | EP | claimed |
| EP-0710367-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-05-08 | — | — | EP | claimed |
| US-5466398-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-11-14 | — | — | US | claimed |
| WO-1995000867-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | claimed |
| US-7166357-B2 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-20040185268-A1 | Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-23 | — | — | US | disclosed |
| EP-0710367-B1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG IND OHIO INC (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5637262-A | REVERSIBLE PHOTOCHROMIC DYES FOR OPHTHALMIC LENSES | TRANSITIONS OPTICAL, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0710367-A4 | — | — | 1996-05-15 | — | — | EP | disclosed |
| EP-0710367-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1996-05-08 | — | — | EP | disclosed |
| US-5466398-A | Photochromic substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1995000867-A1 | PHOTOCHROMIC SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | PPG INDUSTRIES, INC. (US) | 1995-01-05 | — | — | WO | disclosed |