Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 6/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTR5A | P47898 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12533540 | 0.84 | LMNA (0.38) | MAPKAPK2TSHRHTR5AALDH1A1LMNA | |
| SCHEMBL29967921 | 0.84 | AR (0.47) | ARADORA3HSD11B1AKR1C3HTR2A | |
| SCHEMBL237581 | 0.84 | AR (0.47) | ARADORA3HSD11B1AKR1C3HTR2A | |
| SCHEMBL30317690 | 0.80 | AR (0.45) | ARADORA3HSD11B1AKR1C3HTR2A | |
| SCHEMBL6013997 | 0.79 | PTPN1 (0.34) | MAPKAPK2TSHRALDH1A1EGFRCA2 | |
| SCHEMBL3080406 | 0.79 | AR (0.44) | ARADORA3HSD11B1AKR1C3HTR2A | |
| SCHEMBL8889457 | 0.78 | TAAR1 (0.44) | HTR2AHTR2CHTR2BTSHRHTR5A | |
| SCHEMBL4846202 | 0.78 | MAPKAPK2 (0.35) | CYP3A4MAPKAPK2TSHRHTR5AALOX15 | |
| SCHEMBL2177894 | 0.78 | HTR2C (0.40) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL1352303 | 0.78 | TSHR (0.33) | TSHRHTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2370398-B1 | Mixture of amides and cosmetic compositions comprising said mixture | KAO CORP SA (ES) | 2012-10-17 | — | — | EP | disclosed |
| US-8246697-B2 | Mixture of amides and cosmetic compositions comprising said mixture | KAO CORPORATION S.A. (ES) | 2012-08-21 | — | — | US | disclosed |
| US-20120005843-A1 | MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE | Kao Corporation S.A, (ES) | 2012-01-12 | — | — | US | disclosed |
| EP-2370398-A1 | MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE | KAO CORPORATION, S.A. (ES) | 2011-10-05 | — | — | EP | disclosed |
| EP-1714677-B1 | Long chain fatty acid dimethylaminopropylamide as levelling agent for dyeing kerationous fibres | KAO CORP SA (ES) | 2010-07-14 | — | — | EP | disclosed |
| WO-2010072810-A1 | MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE | KAO CORPORATION, S.A. (ES) | 2010-07-01 | — | — | WO | disclosed |
| EP-2202219-A1 | Mixture of amides and cosmetic compositions comprising said mixture | KAO CORPORATION, S.A. (ES) | 2010-06-30 | — | — | EP | disclosed |
| EP-1714677-A1 | Long chain fatty acid dimethylaminopropylamide as levelling agent for dyeing kerationous fibres, or as thickening agent | KAO CORPORATION, S.A. (ES) | 2006-10-25 | — | — | EP | disclosed |
| US-20060084688-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | BARTA THOMAS E | 2006-04-20 | — | — | US | disclosed |
| US-6890937-B2 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION (US) | 2005-05-10 | — | — | US | disclosed |
| US-6750233-B2 | SELECTIVITY | PHARMACIA CORPORATION | 2004-06-15 | — | — | US | disclosed |
| US-20040048852-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2004-03-11 | — | — | US | disclosed |
| US-6541489-B1 | Excellent inhibitory activity of one or more matrix metalloprotease (MMP) enzymes, such as MMP-2, MMP-9, and MMP-13, while exhibiting substantially less inhibition at least of MMP- 1 | G. D. SEARLE & COMPANY | 2003-04-01 | — | — | US | disclosed |
| US-20020177588-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | PHARMACIA CORPORATION | 2002-11-28 | — | — | US | disclosed |
| EP-1230219-A1 | AROMATIC SULFONS HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. Searle & Co. (US) | 2002-08-14 | — | — | EP | disclosed |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | PHARMACIA CORPORATION | 2001-11-08 | — | — | US | disclosed |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | BARTA THOMAS E (US) | 2001-08-16 | — | — | US | disclosed |
| EP-1042290-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-10-11 | — | — | EP | disclosed |
| WO-2000050396-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 2000-08-31 | — | — | WO | disclosed |
| WO-1999025687-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | G.D. SEARLE & CO. (US) | 1999-05-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120005843-A1 | MIXTURE OF AMIDES AND COSMETIC COMPOSITIONS COMPRISING SAID MIXTURE | H1-0, H1-3, H1-4 | AR 407/4885ADORA3 221/4885HSD11B1 671/4885 |
| US-20020177588-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP13, MMP9, MMP10 | AR 2830/4885ADORA3 3993/4885HSD11B1 912/4885 |
| US-20060084688-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP13, MMP9, MMP3 | AR 1524/4885ADORA3 2154/4885HSD11B1 415/4885 |
| US-20010039287-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | AR 2830/4885ADORA3 3993/4885HSD11B1 912/4885 |
| US-20040048852-A1 | Aromatic sulfone hydroxamic acid metalloprotease inhibitor | MMP9, MMP1, MMP13 | AR 1400/4885ADORA3 2454/4885HSD11B1 357/4885 |
| US-20010014688-A1 | AROMATIC SULFONE HYDROXAMIC ACID METALLOPROTEASE INHIBITOR | MMP13, MMP9, MMP10 | AR 2830/4885ADORA3 3993/4885HSD11B1 912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.