Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899524 | 1.00 | ALDH1A1 (0.37) | ALDH1A1KMT2AMEN1MAPTCYP3A4 | |
| SCHEMBL13720973 | 0.86 | ALOX5 (0.41) | ALDH1A1KMT2AMEN1MAPTCYP3A4 | |
| SCHEMBL13899528 | 0.78 | PPARG (0.47) | PPARG | |
| SCHEMBL13899289 | 0.77 | PPARG (0.39) | KMT2AMEN1MAPTPPARGOPRM1 | |
| SCHEMBL14281847 | 0.76 | HIF1A (0.41) | KMT2AMEN1PPARGOPRM1LMNA | |
| SCHEMBL13721776 | 0.76 | ALOX15 (0.42) | ALDH1A1KMT2AMEN1MAPTCYP3A4 | |
| SCHEMBL13721907 | 0.76 | ALOX15 (0.42) | ALDH1A1KMT2AMEN1MAPTCYP3A4 | |
| SCHEMBL4907903 | 0.75 | PPARG (0.45) | ALDH1A1KMT2AMEN1MAPTPPARG | |
| SCHEMBL13899564 | 0.75 | PPARG (0.47) | ALDH1A1KMT2AMEN1MAPTCYP3A4 | |
| SCHEMBL4907904 | 0.75 | PPARG (0.45) | ALDH1A1KMT2AMEN1MAPTPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |