Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.47 |
| ▸ | PPARA | Q07869 | 6/20 | 0.47 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13720973 | 0.86 | ALOX5 (0.41) | PPARGPPARAFAAHALDH1A1GAA | |
| SCHEMBL4907903 | 0.82 | PPARG (0.45) | PPARGPPARAACHEBCHEFAAH | |
| SCHEMBL4907904 | 0.82 | PPARG (0.45) | PPARGPPARAACHEBCHEFAAH | |
| SCHEMBL10184452 | 0.80 | BCHE (0.50) | PPARGPPARAACHEBCHEFAAH | |
| SCHEMBL14281847 | 0.79 | HIF1A (0.41) | PPARGPPARAACHEBCHELMNA | |
| SCHEMBL13899538 | 0.76 | FAAH (0.42) | PPARGPPARAACHEFAAHALDH1A1 | |
| SCHEMBL13721907 | 0.76 | ALOX15 (0.42) | PPARGPPARAALDH1A1GAALMNA | |
| SCHEMBL13721776 | 0.76 | ALOX15 (0.42) | PPARGPPARAALDH1A1GAALMNA | |
| SCHEMBL13899524 | 0.75 | ALDH1A1 (0.37) | PPARGALDH1A1GAALMNAMEN1 | |
| SCHEMBL13899504 | 0.75 | ALDH1A1 (0.37) | PPARGALDH1A1GAALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507757-B2 | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-03-24 | — | — | US | disclosed |