Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13887515 | 0.81 | GRIN2D (0.43) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL28569398 | 0.79 | GAA (0.34) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL28580318 | 0.79 | ALDH1A1 (0.40) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL28945868 | 0.78 | MAPT (0.42) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL14648573 | 0.77 | TAAR1 (0.46) | TAAR1 | |
| SCHEMBL14872978 | 0.77 | PDE2A (0.39) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL18905641 | 0.75 | TSHR (0.48) | APPTSHRSIGMAR1GRIN2DGRIN3B | |
| SCHEMBL13855831 | 0.74 | HTR3E (0.52) | SIGMAR1GRIN2BTAAR1 | |
| SCHEMBL13921656 | 0.73 | GRK2 (0.35) | HDAC1HDAC2HDAC3HDAC8HDAC6 | |
| SCHEMBL14406013 | 0.73 | SLC7A5 (0.51) | HDAC1HDAC2HDAC3HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2962692-A1 | AGENT FOR PREVENTING AND/OR TREATING OCULAR INFLAMMATORY DISEASE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2016-01-06 | — | — | EP | disclosed |
| US-8188241-B2 | Immobilized proteins and methods and uses thereof | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090069548-A1 | Immobilized Proteins and Methods and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069548-A1 | Immobilized Proteins and Methods and Uses Thereof | STUB1, MARCKS, SUMO3 | APP 2422/4885TSHR 3652/4885HDAC1 2135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.