Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B known ✓ | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.40 |
| ▸ | PDE4A known ✓ | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B known ✓ | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C known ✓ | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.37 |
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 6/20 | 0.40 |
| ▸ | PDE5A | O76074 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1392449 | 0.97 | SMPD1 (0.39) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL8448199 | 0.97 | SMPD1 (0.39) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL30311148 | 0.97 | SMPD1 (0.39) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL1619886 | 0.96 | SMPD1 (0.38) | SMPD1PDE3BPDE3APDE5APDE4A | |
| Zinc Ion SCHEMBL1392695 | 0.96 | SMPD1 (0.38) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL15859541 | 0.96 | SMPD1 (0.38) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL1393356 | 0.96 | SMPD1 (0.38) | SMPD1PDE3BPDE3APDE5APDE4A | |
| SCHEMBL28034499 | 0.88 | PDE5A (0.46) | SMPD1PDE5APDE4APDE4BPDE4C | |
| SCHEMBL28035087 | 0.88 | PDE5A (0.46) | SMPD1PDE5APDE4APDE4BPDE4C | |
| SCHEMBL10861583 | 0.85 | PDE3B (0.34) | SMPD1PDE3BPDE3APDE5APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250010575-A1 | Near Infrared Reflecting Composition and Coverings for Architectural Openings Incorporating Same | 3G MERMET CORPORATION | 2025-01-09 | — | — | US | disclosed |
| US-12049071-B2 | Near infrared reflecting composition and coverings for architectural openings incorporating same | 3G MERMET CORPORATION (US) | 2024-07-30 | — | — | US | disclosed |
| US-20190350399-A1 | Near Infrared Reflecting Composition and Coverings for Architectural Openings Incorporating Same | 3G MERMET CORPORATION | 2019-11-21 | — | — | US | disclosed |
| EP-2646637-B1 | NEAR INFRARED REFLECTING COMPOSITION AND COVERINGS FOR ARCHITECTURAL OPENINGS INCORPORATING SAME | 3G MERMET CORP (US) | 2019-05-08 | — | — | EP | disclosed |
| EP-1976691-B1 | SOLAR CONTROL LAMINATES | KURARAY AMERICA INC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-20140335329-A1 | Near Infrared Reflecting Composition and Coverings for Architectural Openings Incorporating Same | 3G MERMET CORPORATION | 2014-11-13 | — | — | US | disclosed |
| US-8278243-B2 | Laser imaging | DATALASE LTD. (GB) | 2012-10-02 | — | — | US | disclosed |
| US-8178206-B2 | Solar control laminates | E I DU PONT DE NEMOURS AND COMPANY (US) | 2012-05-15 | — | — | US | disclosed |
| US-20120010557-A1 | Drug Delivery System for Use in the Treatment of Vascular and Vessel-Related Pathologies | ACADEMISCH MEDISCH CENTRUM (NL) | 2012-01-12 | — | — | US | disclosed |
| EP-2210590-A1 | Drug delivery system for use in the treatment of vascular and vessel-related pathologies | Academisch Medisch Centrum (NL) | 2010-07-28 | — | — | EP | disclosed |
| US-20100096604-A1 | SOLAR CONTROL LAMINATES | E. I. DU PONT DE NEMOURS AND COMPANY (DE) | 2010-04-22 | — | — | US | disclosed |
| US-20100075848-A1 | Laser Imaging | DATALASE LTD. (GB) | 2010-03-25 | — | — | US | disclosed |
| US-7622192-B2 | Solar control laminates | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-11-24 | — | — | US | disclosed |
| EP-1976692-A2 | SOLAR CONTROL LAMINATES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-10-08 | — | — | EP | disclosed |
| US-20080057185-A1 | Solar control laminates | WALL JASON S | 2008-03-06 | — | — | US | disclosed |
| US-20070228340-A1 | Solar control laminates | DOW GLOBAL TECHNOLOGIES LLC | 2007-10-04 | — | — | US | disclosed |
| US-20070228341-A1 | Solar control laminates | E. I. DU PONT DE NEMOURS AND COMPANY | 2007-10-04 | — | — | US | disclosed |
| WO-2007079249-A2 | SOLAR CONTROL LAMINATES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-07-12 | — | — | WO | disclosed |
| US-20070009714-A1 | Polymeric interlayers having a wedge profile | E. I. DU PONT DE NEMOURS AND COMPANY | 2007-01-11 | — | — | US | disclosed |