Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 6/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | CCND1 | P24385 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL172127 | 0.75 | ALDH1A1 (0.58) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL18711688 | 0.74 | CDK4 (0.35) | ALDH1A1L3MBTL1CDK4CCND1KDM4E | |
| SCHEMBL18701513 | 0.74 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL9996283 | 0.71 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL19503273 | 0.71 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL8058002 | 0.71 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL10865995 | 0.69 | — | — | |
| SCHEMBL12621292 | 0.68 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL19503077 | 0.68 | ALDH1A1 (0.50) | ALDH1A1L3MBTL1SMN1; SMN2PARP1TNKS2 | |
| SCHEMBL22587346 | 0.68 | SMN1; SMN2 (0.49) | ALDH1A1L3MBTL1SMN1; SMN2MAPK1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356345-B1 | HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2023-11-08 | — | — | EP | disclosed |
| US-20170096435-A1 | SEPIAPTERIN REDUCTASE INHIBITORS | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2017-04-06 | — | — | US | disclosed |
| US-7488824-B2 | Process for the production of substituted nicotinic acid esters | SYNGENTA CROP PROTECTION, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| US-7488824-B2 | Process for the production of substituted nicotinic acid esters | SYNGENTA CROP PROTECTION, INC. (US) | 2009-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096435-A1 | SEPIAPTERIN REDUCTASE INHIBITORS | SPR, QDPR, SRR | ALDH1A1 374/4885L3MBTL1 1901/4885SMN1; SMN2 2655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.