Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 6/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13934652 | 0.75 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1PARP1TNKS2 | |
| SCHEMBL8058002 | 0.75 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1KMT2APARP1 | |
| SCHEMBL9996283 | 0.75 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1MAPK1PARP1TNKS2 | |
| SCHEMBL718210 | 0.75 | NPSR1 (0.52) | ALDH1A1L3MBTL1MAPK1KMT2AMAPT | |
| SCHEMBL3390495 | 0.75 | KMT2A (0.41) | ALDH1A1L3MBTL1KMT2APARP1SMN1; SMN2 | |
| SCHEMBL13406334 | 0.75 | ALDH1A1 (0.43) | ALDH1A1L3MBTL1MAPK1KMT2APARP1 | |
| SCHEMBL18950161 | 0.72 | KDM4C (0.46) | ALDH1A1KMT2AGAASMN1; SMN2POLB | |
| SCHEMBL15470617 | 0.72 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1MAPK1PARP1TNKS2 | |
| SCHEMBL9616337 | 0.72 | L3MBTL1 (0.54) | ALDH1A1L3MBTL1KMT2ATNKS2SMN1; SMN2 | |
| SCHEMBL11990814 | 0.72 | GAA (0.59) | ALDH1A1L3MBTL1MAPK1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3356345-B1 | HETEROARYL DERIVATIVES AS SEPIAPTERIN REDUCTASE INHIBITORS | MAX PLANCK GESELLSCHAFT (DE) | 2023-11-08 | — | — | EP | disclosed |
| US-11542505-B1 | Substituted RIG-I agonists: compositions and methods thereof | MERCK SHARP & DOHME LLC (US) | 2023-01-03 | — | — | US | disclosed |
| EP-3573718-B1 | CYCLIC DINUCLEOTIDES AS STING AGONISTS | JANSSEN BIOTECH INC (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3885343-A1 | INDOLE COMPOUNDS AS EZH2 INHIBITORS AND USES THEREOF | Dana-Farber Cancer Institute, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| US-20210147467-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | INNATE TUMOR IMMUNITY INC (US) | 2021-05-20 | — | — | US | disclosed |
| US-10961270-B2 | Compounds and compositions for treating conditions associated with sting activity | INNATE TUMOR IMMUNITY, INC. (US) | 2021-03-30 | — | — | US | disclosed |
| WO-2020239107-A1 | TETRACYCLIC COMPOUNDS AS CDC7 INHIBITORS | 正大天晴药业集团股份有限公司 | 2020-12-03 | — | — | WO | disclosed |
| US-20200165288-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | INNATE TUMOR IMMUNITY INC (US) | 2020-05-28 | — | — | US | disclosed |
| US-9809598-B2 | Heterocyclyl-butanamide derivatives | MERCK PATENT GMBH (DE) | 2017-11-07 | — | — | US | disclosed |
| WO-2017184999-A1 | EZH2 INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-10-26 | — | — | WO | disclosed |
| EP-2213674-B1 | PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS | CHONGQING PHARM RES INST CO (CN) | 2012-03-07 | — | — | EP | disclosed |
| US-20100305319-A1 | METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED | Chongquing Pharmaceutical Research Institute Co. ltd (CN) | 2010-12-02 | — | — | US | disclosed |
| US-20100305319-A1 | METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED | Chongquing Pharmaceutical Research Institute Co. ltd (CN) | 2010-12-02 | — | — | US | disclosed |
| EP-2213674-A1 | PURIFICATION METHOD OF PEMETREXED SALTS,SODIUM SALTS AND DISODIUM SALTS | Chongqing Pharmaceutical Research Institute Co., Ltd. (CN) | 2010-08-04 | — | — | EP | disclosed |
| US-7767626-B2 | 3-arylphenyl sulfide derivative and insecticide and miticide | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-7612105-B2 | 3-arylphenyl sulfide derivative and insecticide and miticide | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-11-03 | — | — | US | disclosed |
| US-20090170883-A1 | 3-ARYLPHENYL SULFIDE DERIVATIVE AND INSECTICIDE AND MITICIDE | KUMIAI CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-0153746-B1 | 3-AMINO-2-HYDROXYPROPYL DERIVATIVES OF PYRIMIDIN-4-ONE | MERCK & CO. INC. (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4598149-A | ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1986-07-01 | — | — | US | disclosed |
| EP-0153746-A2 | 3-Amino-2-hydroxypropyl derivatives of pyrimidin-4-one | MERCK & CO. INC. (US) | 1985-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961270-B2 | Compounds and compositions for treating conditions associated with sting activity | STING1, CGAS, IRF3 | ALDH1A1 4624/4885L3MBTL1 2384/4885MAPK1 1629/4885 |
| US-20100305319-A1 | METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED | SLC13A3, SLC34A3, SLC28A1 | ALDH1A1 2625/4885L3MBTL1 2850/4885MAPK1 779/4885 |
| US-20090170883-A1 | 3-ARYLPHENYL SULFIDE DERIVATIVE AND INSECTICIDE AND MITICIDE | CBR3, MSRB3, CYP1B1 | ALDH1A1 457/4885L3MBTL1 222/4885MAPK1 3364/4885 |
| US-20200165288-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | STING1, CGAS, IRF3 | ALDH1A1 4624/4885L3MBTL1 2384/4885MAPK1 1629/4885 |
| US-11542505-B1 | Substituted RIG-I agonists: compositions and methods thereof | MAVS, TLR3, DDX18 | ALDH1A1 2726/4885L3MBTL1 817/4885MAPK1 3081/4885 |
| US-20210147467-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY | STING1, CGAS, IRF3 | ALDH1A1 4624/4885L3MBTL1 2384/4885MAPK1 1629/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.