Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGLV6-57 | P01721 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | GLA | P06280 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | CASP1 | P29466 | 3/20 | 0.49 |
| ▸ | CASP7 | P55210 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5964558 | 0.84 | ALDH1A1 (0.72) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL67970 | 0.82 | IGLV6-57 (0.72) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL29401382 | 0.82 | IGLV6-57 (0.72) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL31463116 | 0.79 | NPC1 (0.49) | ALDH1A1HPGDGLAHSD17B10CASP1 | |
| SCHEMBL12809788 | 0.79 | NPC1 (0.49) | ALDH1A1HPGDGLAHSD17B10CASP1 | |
| SCHEMBL27473166 | 0.78 | IGLV6-57 (0.48) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL2671892 | 0.78 | IGLV6-57 (0.50) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL29266170 | 0.78 | IGLV6-57 (0.50) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL8113826 | 0.78 | ALDH1A1 (0.70) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 | |
| SCHEMBL28578061 | 0.78 | ALDH1A1 (0.70) | IGLV6-57ALDH1A1HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458910-B | Mitochondrial aldehyde dehydrogenase 2(ALDH2) binding polycyclic amides and their use for treating cancer | 亚倍生技制药公司 | 2020-11-06 | — | — | CN | disclosed |
| EP-3107899-B1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE 2 (ALDH2) BINDING POLYCYCLIC AMIDES AND THEIR USE FOR THE TREATMENT OF CANCER | AVIV THERAPEUTICS INC (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-2970124-B1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | UNIV LELAND STANFORD JUNIOR (US) | 2019-05-22 | — | — | EP | disclosed |
| US-10227304-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-03-12 | — | — | US | disclosed |
| US-9879036-B2 | Mitochondrial aldehyde dehydrogenase-2 binding compounds and methods of use thereof | AVIV THERAPEUTICS, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| CN-105358531-B | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | 利兰-斯坦福大学初级学院的董事会 | 2017-11-14 | — | — | CN | disclosed |
| US-20170320828-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2017-11-09 | — | — | US | disclosed |
| US-9670162-B2 | Mitochondrial aldehyde dehyrogenase-2 modulators and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIO (US) | 2017-06-06 | — | — | US | disclosed |
| US-20170057982-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 BINDING COMPOUNDS AND METHODS OF USE THEREOF | AVIV THERAPEUTICS, INC. (US) | 2017-03-02 | — | — | US | disclosed |
| CN-106458910-A | Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer | 亚倍生技制药公司 | 2017-02-22 | — | — | CN | disclosed |
| US-8906942-B2 | Modulators of aldhehyde dehydrogenase activity and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-12-09 | — | — | US | disclosed |
| WO-2014160185-A2 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 MODULATORS AND METHODS OF USE THEREOF | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-10-02 | — | — | WO | disclosed |
| US-8772295-B2 | Modulators of aldehyde dehydrogenase and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2014-07-08 | — | — | US | disclosed |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-10-10 | — | — | US | disclosed |
| US-20130253010-A1 | Modulators of Aldhehyde Dehydrogenase Activity and Methods of Use Thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-09-26 | — | — | US | disclosed |
| US-8354435-B2 | Modulators of aldehyde dehydrogenase activity and methods of use thereof | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2013-01-15 | — | — | US | disclosed |
| US-20120010248-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-01-12 | — | — | US | disclosed |
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-05-05 | — | — | US | disclosed |
| US-20100063100-A1 | MODULATORS OF ALDEHYDE DEHYDROGENASE ACTIVITY AND METHODS OF USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-11 | — | — | US | disclosed |
| CN-101669030-A | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | UNIV LELAND STANFORD JUNIOR | 2010-03-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105602-A2 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | IGLV6-57 4725/4885ALDH1A1 13/4885HPGD 184/4885 |
| US-20130253010-A1 | Modulators of Aldhehyde Dehydrogenase Activity and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IGLV6-57 4433/4885ALDH1A1 3/4885HPGD 28/4885 |
| US-20130267501-A1 | Modulators of Aldehyde Dehydrogenase and Methods of Use Thereof | ALDH2, ALDH3A1, ALDH1A1 | IGLV6-57 4019/4885ALDH1A1 3/4885HPGD 86/4885 |
| US-20170057982-A1 | MITOCHONDRIAL ALDEHYDE DEHYDROGENASE-2 BINDING COMPOUNDS AND METHODS OF USE THEREOF | ALDH2, DLD, ALDH5A1 | IGLV6-57 3671/4885ALDH1A1 25/4885HPGD 386/4885 |
| US-20120010248-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, AK2 | IGLV6-57 4725/4885ALDH1A1 13/4885HPGD 184/4885 |
| US-20100063100-A1 | MODULATORS OF ALDEHYDE DEHYDROGENASE ACTIVITY AND METHODS OF USE THEREOF | ALDH2, ALDH3A1, ALDH1A1 | IGLV6-57 4506/4885ALDH1A1 3/4885HPGD 41/4885 |
| US-20170320828-A1 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof | ALDH2, ALDH5A1, DLD | IGLV6-57 4705/4885ALDH1A1 68/4885HPGD 249/4885 |
| US-10227304-B2 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof | ALDH2, ALDH5A1, DLD | IGLV6-57 4705/4885ALDH1A1 68/4885HPGD 249/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.