Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.47 |
| ▸ | PADI1 | Q9ULC6 | 4/20 | 0.47 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PADI2 | Q9Y2J8 | 3/20 | 0.47 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15271466 | 1.00 | BCHE (0.48) | BCHEACHEC3AR1CYP26A1PADI1 | |
| SCHEMBL24732379 | 0.91 | NAAA (0.54) | BCHEACHECYP26A1CA1CA2 | |
| SCHEMBL562113 | 0.91 | BCHE (0.47) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL80453 | 0.91 | BCHE (0.47) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL30925057 | 0.90 | CA1 (0.56) | C3AR1CYP26A1PADI1PADI4PDE4A | |
| Hydrochloric Acid SCHEMBL538996 | 0.90 | BCHE (0.46) | BCHEACHECYP26A1PADI1PADI4 | |
| Hydrochloric Acid SCHEMBL11325263 | 0.90 | BCHE (0.46) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL15739025 | 0.90 | BCHE (0.46) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL15231556 | 0.84 | C3AR1 (0.60) | C3AR1PADI1PADI4PDE4APADI2 | |
| SCHEMBL7864695 | 0.84 | ITGB3 (0.50) | BCHEACHECYP26A1GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404647-B2 | Peptidylarginine deiminase (PAD) inhibitors | CHIRALIX B.V. (NL) | 2013-03-26 | — | — | US | disclosed |
| EP-2288616-B1 | PEPTIDYLARGININE DEIMINASE (PAD) INHIBITORS | CHIRALIX B V (NL) | 2012-11-21 | — | — | EP | disclosed |
| US-20110142868-A1 | Peptidylarginine Deiminase (PAD) Inhibitors | CHIRALIX B.V. (NL) | 2011-06-16 | — | — | US | disclosed |
| EP-2288616-A1 | PEPTIDYLARGININE DEIMINASE (PAD) INHIBITORS | Chiralix B.V. (NL) | 2011-03-02 | — | — | EP | disclosed |
| WO-2010005293-A1 | PEPTIDYLARGININE DEIMINASE (PAD) INHIBITORS | CHIRALIX B.V. (NL) | 2010-01-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110142868-A1 | Peptidylarginine Deiminase (PAD) Inhibitors | PADI4, PADI2, PADI3 | BCHE 375/4885ACHE 1070/4885C3AR1 1142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.