Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE known ✓ | P06276 | 2/20 | 0.46 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.46 |
| ▸ | PDE4A known ✓ | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B known ✓ | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C known ✓ | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D known ✓ | Q08499 | 2/20 | 0.45 |
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.45 |
| ▸ | GRIN1 known ✓ | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A known ✓ | Q12879 | 1/20 | 0.41 |
| ▸ | P2RY12 known ✓ | Q9H244 | 1/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.45 |
| ▸ | PADI1 | Q9ULC6 | 4/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.45 |
| ▸ | PADI2 | Q9Y2J8 | 3/20 | 0.45 |
| ▸ | PADI3 | Q9ULW8 | 3/20 | 0.45 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL538996 | 1.00 | BCHE (0.46) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL80453 | 0.99 | BCHE (0.47) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL562113 | 0.99 | BCHE (0.47) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL15739025 | 0.98 | BCHE (0.46) | BCHEACHECYP26A1PADI1PADI4 | |
| Hydrochloric Acid SCHEMBL29401063 | 0.91 | CA1 (0.53) | CYP26A1PADI1PADI4PDE4APADI2 | |
| SCHEMBL158087 | 0.90 | CA1 (0.54) | CYP26A1PADI1PADI4PDE4APADI2 | |
| SCHEMBL31206858 | 0.90 | CA1 (0.54) | CYP26A1PADI1PADI4PDE4APADI2 | |
| SCHEMBL16289858 | 0.90 | CA1 (0.54) | CYP26A1PADI1PADI4PDE4APADI2 | |
| SCHEMBL1396385 | 0.90 | BCHE (0.48) | BCHEACHECYP26A1PADI1PADI4 | |
| SCHEMBL15271466 | 0.90 | BCHE (0.48) | BCHEACHECYP26A1PADI1PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126991-A | Method for improving trypsin thermal stability through multi-fragment insertion | 湖北时珍全健康研究有限公司 | 2024-06-04 | — | — | CN | disclosed |
| CN-118006591-A | Method for increasing trypsin degradation efficiency by continuous site mutation | 湖北时珍全健康研究有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-114657196-B | Porcine trypsinogen mutant and expression thereof in pichia pastoris | 江苏万邦医药科技有限公司 | 2024-03-01 | — | — | CN | disclosed |
| US-20230002750-A1 | PREPARATION OF ADIPOSE TISSUE-DERIVED CELL POPULATION | AMANO ENZYME INC. (JP) | 2023-01-05 | — | — | US | disclosed |
| CN-114657196-A | Porcine trypsinogen mutant and expression thereof in pichia pastoris | 江苏万邦医药科技有限公司 | 2022-06-24 | — | — | CN | disclosed |
| WO-2021112168-A1 | PREPARATION OF ADIPOSE TISSUE-DERIVED CELL POPULATION | 天野エンザイム株式会社 | 2021-06-10 | — | — | WO | disclosed |
| CN-109971774-A | A kind of bovine trypsinogen mutant, encoding gene and its preparation | 江苏万邦医药科技有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-108018277-A | Recombined bovine pancreas protease mutant and preparation method thereof | 江苏万邦生化医药股份有限公司 | 2018-05-11 | — | — | CN | disclosed |
| CN-104049082-B | Human tissue kallikrein activity detection kit and application thereof | TONGJI HOSPITAL AFFILIATED TO TONGJI MEDICAL COLLEGE OF HUAZHONG UNIVERSITY OF SCIENCE & TECHNOLOGY (CN) | 2016-03-16 | — | — | CN | disclosed |
| CN-104049082-A | Human tissue kallikrein activity detection kit and application thereof | AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH | 2014-09-17 | — | — | CN | disclosed |
| US-4246351-A | COMPRISING POROUS ADDITION COPOLYMERS | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1981-01-20 | — | — | US | disclosed |