Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13950163 | 0.82 | HTR6 (0.46) | HTR6DRD2CYP19A1HSD11B1MEN1 | |
| SCHEMBL16181048 | 0.81 | HSD11B1 (0.40) | HSD11B1HTR2C | |
| SCHEMBL16181071 | 0.79 | HTR6 (0.47) | HTR6HSD11B1KMT2A | |
| SCHEMBL16181047 | 0.79 | HTR6 (0.42) | HTR6CYP19A1HSD11B1MEN1KMT2A | |
| SCHEMBL9946557 | 0.76 | RBP4 (0.43) | MEN1KMT2AHTR2C | |
| SCHEMBL7963965 | 0.76 | PDE4A (0.50) | NR3C1 | |
| SCHEMBL10569317 | 0.76 | CYP19A1 (0.48) | HTR6CYP19A1HSD11B1MEN1KMT2A | |
| SCHEMBL26410230 | 0.76 | CYP19A1 (0.48) | HTR6CYP19A1HSD11B1MEN1KMT2A | |
| SCHEMBL16181053 | 0.74 | HTR6 (0.38) | HTR6DRD2HSD11B1KMT2ATSHR | |
| SCHEMBL6584136 | 0.74 | PDE4B (0.40) | HTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865707-B2 | Cholesteryl ester transfer protein inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-10-21 | — | — | US | disclosed |
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | MERCK SHARP & DOHME LLC | 2009-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018054-A1 | Cholesteryl Ester Transfer Protein Inhibitors | CETP, APOB, MTTP | HTR6 4355/4885DRD2 4849/4885CYP19A1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.