Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | CDK8 | P49336 | 3/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1386968 | 0.89 | MEN1 (0.37) | TRPM8SLC2A1HDAC11HDAC8HDAC6 | |
| SCHEMBL1397684 | 0.86 | TRPM8 (0.37) | TRPM8CDK8SLC2A1HDAC11HDAC8 | |
| SCHEMBL1386856 | 0.86 | PPARG (0.35) | SLC2A1HDAC11HDAC8HDAC6MGLL | |
| SCHEMBL20768023 | 0.85 | SLC2A1 (0.38) | TRPM8CDK8SLC2A1HDAC8MEN1 | |
| SCHEMBL1397688 | 0.83 | TRPM8 (0.34) | TRPM8CDK8SLC2A1HDAC11HDAC8 | |
| SCHEMBL1397717 | 0.82 | MCL1 (0.34) | CDK8SLC2A1HDAC11HDAC8HDAC6 | |
| SCHEMBL1397592 | 0.80 | HCRTR1 (0.37) | TRPM8HCRTR1HCRTR2SLC2A1HDAC11 | |
| SCHEMBL1386237 | 0.79 | ESRRG (0.34) | TRPM8HDAC11HDAC8HDAC6 | |
| SCHEMBL1386433 | 0.79 | TRPV1 (0.35) | TRPM8CDK8HDAC11HDAC8HDAC6 | |
| SCHEMBL1385947 | 0.78 | ESRRG (0.36) | HDAC11HDAC8HDAC6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |