Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | EIF4E | P06730 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397684 | 0.86 | TRPM8 (0.37) | TRPM8CDK8SLC2A1MGLLHDAC11 | |
| SCHEMBL1386968 | 0.86 | MEN1 (0.37) | TRPM8SLC2A1MGLLHDAC11HDAC8 | |
| SCHEMBL1397717 | 0.84 | MCL1 (0.34) | CDK8SLC2A1MGLLHDAC11HDAC8 | |
| SCHEMBL20768023 | 0.83 | SLC2A1 (0.38) | TRPM8CDK8SLC2A1MGLLHDAC8 | |
| SCHEMBL1397553 | 0.83 | TRPM8 (0.35) | TRPM8CDK8SLC2A1MGLLHDAC11 | |
| SCHEMBL1386856 | 0.83 | PPARG (0.35) | SLC2A1MGLLHDAC11HDAC8HDAC6 | |
| SCHEMBL1397700 | 0.78 | MCL1 (0.31) | MGLLMCL1 | |
| SCHEMBL4661382 | 0.76 | GPR52 (0.37) | GPR52MEN1KMT2A | |
| SCHEMBL3195141 | 0.76 | LMNA (0.39) | CETP | |
| SCHEMBL1386237 | 0.75 | ESRRG (0.34) | TRPM8HDAC11HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |