Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 4/20 | 0.32 |
| ▸ | CHUK | O15111 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | F12 | P00748 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397642 | 0.88 | MEN1 (0.35) | MAPTTP53HSD17B10ALDH1A1 | |
| SCHEMBL1397640 | 0.88 | IKBKB (0.38) | MAPTIKBKBCHUKHPGDMAOB | |
| SCHEMBL1397538 | 0.86 | THRB (0.32) | MAPTTP53IKBKBCHUKPOLB | |
| SCHEMBL1397731 | 0.85 | TP53 (0.32) | MAPTTP53IKBKBCHUKMAOB | |
| SCHEMBL1397443 | 0.85 | OPRM1 (0.31) | IKBKBCHUK | |
| SCHEMBL1397686 | 0.85 | TP53 (0.35) | MAPTTP53IKBKBCHUKMAOB | |
| SCHEMBL1397802 | 0.85 | MAOB (0.36) | MAPTTP53IKBKBCHUKMAOB | |
| SCHEMBL1397655 | 0.85 | MAPT (0.35) | MAPTTP53IKBKBCHUKMAOB | |
| SCHEMBL1397462 | 0.83 | CCR2 (0.35) | HPGDMAOB | |
| SCHEMBL1397826 | 0.80 | C5AR1 (0.35) | MAPTTP53IKBKBCHUKMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |