Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1397731 | 0.93 | TP53 (0.32) | MAOBCNR1TP53MAPTIKBKB | |
| SCHEMBL1397686 | 0.92 | TP53 (0.35) | MAOBTP53MAPTIKBKBCHUK | |
| SCHEMBL1397538 | 0.89 | THRB (0.32) | MAOBTP53MAPTIKBKBCHUK | |
| SCHEMBL1397640 | 0.89 | IKBKB (0.38) | MAOBMAPTIKBKBCHUKMAOA | |
| SCHEMBL1397443 | 0.89 | OPRM1 (0.31) | IKBKBCHUK | |
| SCHEMBL1397462 | 0.88 | CCR2 (0.35) | MAOB | |
| SCHEMBL1397655 | 0.87 | MAPT (0.35) | MAOBTP53MAPTIKBKBCHUK | |
| SCHEMBL1397683 | 0.85 | MAPT (0.33) | MAOBTP53MAPTHDAC6IKBKB | |
| SCHEMBL1397642 | 0.85 | MEN1 (0.35) | TP53MAPT | |
| SCHEMBL1397663 | 0.77 | C5AR1 (0.34) | MAOBTP53MAPTIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007726-B1 | BENZAMIDE AND HETEROARENE DERIVATIVES AS CETP INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-02 | — | — | EP | disclosed |