Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BACE1 | P56817 | 4/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | TLR2 | O60603 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13983293 | 0.82 | APP (0.47) | MAPTAPPTLR8 | |
| SCHEMBL13982786 | 0.81 | MAPT (0.47) | NPC1RAB9AMAPTTLR4TLR2 | |
| SCHEMBL13983155 | 0.79 | MAPT (0.50) | NPC1RAB9AMAPTBACE1TLR4 | |
| SCHEMBL13982697 | 0.78 | MAPT (0.49) | NPC1RAB9AMAPTTLR4TLR2 | |
| SCHEMBL13982785 | 0.76 | MAPT (0.41) | NPC1RAB9AMAPTTLR4TLR2 | |
| SCHEMBL668203 | 0.76 | KDM4E (0.48) | NPC1RAB9AMAPTCYP1A2CYP19A1 | |
| SCHEMBL4583260 | 0.75 | ALDH1A1 (0.53) | RAB9AMAPTTLR8TSHR | |
| SCHEMBL13656495 | 0.75 | HRH2 (0.57) | NPC1RAB9AMAPTSMN1; SMN2HRH2 | |
| SCHEMBL7622534 | 0.74 | NPC1 (0.41) | NPC1RAB9AMAPTTLR4TLR2 | |
| SCHEMBL13982734 | 0.74 | GRIN2D (0.42) | NPC1RAB9AMAPTTLR8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008156656-A2 | METHOD FOR MAKING BIARYL COMPOUNDS, COMPOUNDS MADE BY THE METHOD, AND METHOD FOR THEIR USE | STATE OF OREGON ACTING BY AND THROUGH THE STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 2008-12-24 | — | — | WO | disclosed |