SCHEMBL1398281

SCHEMBL1398281

CC=CC(=O)OCCC[Si](C)(C)O[Si](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 4/20 0.37
AKR1B10 O60218 5/20 0.36
AKR1B1 P15121 5/20 0.36
ALOX5 P09917 1/20 0.35
MAPT P10636 2/20 0.35
ATM Q13315 1/20 0.34
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
TTR P02766 1/20 0.34
EGFR P00533 1/20 0.33
BTK Q06187 1/20 0.33
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9764056 0.91 HCAR2 (0.38) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL5898832 0.88 HCAR2 (0.38) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL9763748 0.88 HCAR2 (0.35) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL16205162 0.87 HCAR2 (0.37) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL22092326 0.84 HCAR2 (0.40) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL4623580 0.84 HCAR2 (0.40) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL16205020 0.83 HCAR2 (0.38) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL7794491 0.83 HCAR2 (0.39) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL17373023 0.82 HCAR2 (0.41) HCAR2AKR1B10AKR1B1ALOX5MAPT
SCHEMBL17287255 0.82 HCAR2 (0.41) HCAR2AKR1B10AKR1B1ALOX5MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945231-B1 CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL ROCHAL PARTNERS LLP (US) 2021-11-10 EP claimed
EP-2764065-B1 SACRIFICIAL ADHESIVE COATINGS ROCHAL IND LLC (US) 2017-03-22 EP claimed
US-8784793-B2 Conformable solvent-based bandage and coating material ROCHAL INDUSTRIES, LLP (US) 2014-07-22 US claimed
US-20130303654-A1 CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL ROCHAL INDUSTRIES LLP (US) 2013-11-14 US claimed
US-8263720-B1 Sacrificial adhesive coatings ROCHAL INDUSTRIES, LLP (US) 2012-09-11 US claimed
US-8197803-B2 Method of forming a conformable solvent-based bandage and coating material ROCHAL INDUSTRIES, LLP (US) 2012-06-12 US claimed
US-20120114729-A1 SILICONE-PEROXIDE COMPOSITIONS FOR LONG-TERM, CONTROLLED OXYGEN RELEASE UNIVERSITY OF MIAMI (US) 2012-05-10 US claimed
WO-2010121024-A2 SILICONE-PEROXIDE COMPOSITIONS FOR LONG-TERM, CONTROLLED OXYGEN RELEASE UNIVERSITY OF MIAMI (US) 2010-10-21 WO claimed
US-20090210002-A1 METHOD OF FORMING A CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL ROCHAL INDUSTRIES LLP (US) 2009-08-20 US claimed
EP-1945231-A2 CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL Salamone, Ann Beal (US) 2008-07-23 EP claimed
WO-2007022377-A2 CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL SALAMONE ANN BEAL (US) 2007-02-22 WO claimed
US-20070041935-A1 Polymerizable cyanoacrylate monomer and volatile liquid selected from linear and cyclic siloxanes, polydimethylsiloxanes, isooctane, and octane; kits ROCHAL PARTNERS LLP 2007-02-22 US claimed
US-11839626-B2 Composition and kits for inhibition of pathogenic microbial infection and methods of using the same ROCHAL TECHNOLOGIES LLC (US) 2023-12-12 US disclosed
EP-1945231-B1 CONFORMABLE SOLVENT-BASED BANDAGE AND COATING MATERIAL ROCHAL PARTNERS LLP (US) 2021-11-10 EP disclosed
EP-3220741-B1 COMPOSITION AND KITS FOR INHIBITION OF PATHOGENIC MICROBIAL INFECTION AND METHODS OF USING THE SAME ROCHAL IND LLC (US) 2021-02-24 EP disclosed
EP-3052140-B1 NON-SELF-ADHERENT COATING MATERIALS ROCHAL IND LLC (US) 2019-05-01 EP disclosed
EP-1465903-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2004-10-13 EP disclosed
EP-1448572-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2004-08-25 EP disclosed
WO-2003040157-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO disclosed
WO-2003040158-A1 HIGH REFRACTIVE INDEX POLYMERIC SILOXYSILANE COMPOSITIONS BAUSCH & LOMB INCORPORATED (US) 2003-05-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11839626-B2 Composition and kits for inhibition of pathogenic microbial infection and methods of using the same CUTA, MMP8, MMP1 HCAR2 3862/4885AKR1B10 2122/4885AKR1B1 3174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.