SCHEMBL1398747

SCHEMBL1398747

Cc1sc2ccccc2c1C(=O)O

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRNP P04156 1/20 0.53
RXFP1 Q9HBX9 1/20 0.53
LMNA P02545 2/20 0.49
MAPK1 P28482 1/20 0.49
MCL1 Q07820 1/20 0.49
ABCC1 P33527 2/20 0.48
ABCG2 Q9UNQ0 1/20 0.48
ACLY P53396 2/20 0.43
PDE10A Q9Y233 1/20 0.43
ALDH1A1 P00352 3/20 0.43
TDP1 Q9NUW8 3/20 0.43
POLB P06746 1/20 0.43
GPR3 P46089 1/20 0.43
KDM4E B2RXH2 2/20 0.43
HPGD P15428 2/20 0.43
MEN1 O00255 1/20 0.42
CYP1A2 P05177 1/20 0.42
GLA P06280 1/20 0.42
CYP2C19 P33261 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29448323 1.00 PRNP (0.53) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL9756952 0.85 LMNA (0.46) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL9756955 0.85 LMNA (0.46) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL9556945 0.85 LMNA (0.49) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL31350344 0.83 LIMK1 (0.56) PRNPRXFP1LMNAMAPK1MCL1
Hydrochloric Acid SCHEMBL7300365 0.81 LIMK1 (0.54) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL3599532 0.80 LMNA (0.71) LMNAMAPK1ALDH1A1TDP1KDM4E
SCHEMBL5399193 0.79 LMNA (0.44) PRNPRXFP1LMNAMAPK1ABCC1
SCHEMBL6840465 0.79 LMNA (0.41) PRNPRXFP1LMNAMAPK1MCL1
SCHEMBL6840468 0.79 LMNA (0.41) PRNPRXFP1LMNAMAPK1MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN disclosed
WO-2023277630-A1 GALACTOSIDE DERIVATIVE AS GALECTIN-3 INHIBITOR 주식회사 티움바이오 2023-01-05 WO disclosed
CN-109475530-B Aminoacyl indazole immunomodulators for treating autoimmune diseases 洛克菲勒大学 2022-03-01 CN disclosed
US-20190202811-A1 AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES THE ROCKEFELLER UNIVERSITY (US) 2019-07-04 US disclosed
US-20190202811-A1 AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES THE ROCKEFELLER UNIVERSITY (US) 2019-07-04 US disclosed
EP-3463341-A1 AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES The Rockefeller University (US) 2019-04-10 EP disclosed
CN-109475530-A For treating the aminoacyl indazole immunomodulator of autoimmune disease 洛克菲勒大学 2019-03-15 CN disclosed
US-9872493-B2 Method for promoting plant growth SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-01-23 US disclosed
US-9872493-B2 Method for promoting plant growth SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-01-23 US disclosed
WO-2017205296-A1 AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES THE ROCKEFELLER UNIVERSITY (US) 2017-11-30 WO disclosed
US-7981904-B2 Acetyl CoA carboxylase inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-07-19 US disclosed
EP-2069332-B1 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2011-03-02 EP disclosed
US-20100222600-A1 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD. (CH) 2010-09-02 US disclosed
US-20100160255-A1 SPIRO-CYCLIC COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-06-24 US disclosed
US-20090253725-A1 ACETYL CoA CARBOXYLASE INHIBITORS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-10-08 US disclosed
EP-2069332-A2 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS Actelion Pharmaceuticals Ltd. (CH) 2009-06-17 EP disclosed
EP-1911753-A1 SPIRO-CYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2008-04-16 EP disclosed
WO-2008020405-A2 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2008-02-21 WO disclosed
US-5189041-A Gastrointestinal and nervous system disorders, cardiovascular disorders, analgesics SYNTEX (U.S.A.) INC. (US) 1993-02-23 US disclosed
EP-0485962-A2 New tricyclic compounds SYNTEX (U.S.A.) INC. (US) 1992-05-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090253725-A1 ACETYL CoA CARBOXYLASE INHIBITORS ACACA, ACACB, ACAT1 PRNP 4761/4885RXFP1 4107/4885LMNA 2862/4885
US-20100222600-A1 AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS HCRTR2, HCRTR1, NPY1R PRNP 2737/4885RXFP1 17/4885LMNA 3973/4885
US-20100160255-A1 SPIRO-CYCLIC COMPOUND ACACA, CPT1B, PC PRNP 4872/4885RXFP1 2242/4885LMNA 1022/4885
US-20190202811-A1 AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES TFPI2, IL4I1, TFPI PRNP 4517/4885RXFP1 4465/4885LMNA 3993/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.