Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC25A20 | O43772 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286569 | 0.82 | TSHR (0.52) | LMNAEPHX2ALDH1A1PLA2G4APLA2G2A | |
| SCHEMBL13991878 | 0.79 | CYP1A2 (0.48) | EPHX2ALDH1A1PLA2G4ACYP2D6KDM4E | |
| SCHEMBL5808280 | 0.79 | LMNA (0.53) | LMNAEPHX2ALDH1A1MAPTMAPK1 | |
| SCHEMBL13991880 | 0.77 | EPHX2 (0.44) | EPHX2PLA2G4APLA2G2AMEN1KMT2A | |
| SCHEMBL13991921 | 0.76 | TSHR (0.55) | LMNAEPHX2ALDH1A1PLA2G4APLA2G2A | |
| SCHEMBL26253430 | 0.75 | MEN1 (0.50) | PLA2G4APLA2G2AMAPK1KDM4EMEN1 | |
| SCHEMBL27372304 | 0.75 | LMNA (0.58) | LMNAEPHX2ALDH1A1MAPTMAPK1 | |
| SCHEMBL13991911 | 0.75 | ALDH1A1 (0.51) | EPHX2ALDH1A1PLA2G4APLA2G2ACYP3A4 | |
| SCHEMBL13286572 | 0.74 | PLA2G4A (0.68) | EPHX2ALDH1A1PLA2G4APLA2G2AMAPT | |
| SCHEMBL8851730 | 0.74 | LMNA (0.57) | LMNAEPHX2ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319065-A1 | Systemic and Intrathecal Effects of a Novel Series of Phospholipase A2 Inhibitors on Hyperalgesia and Spinal Pge2 Release | PLA2G4A, PLA2G4B, PLA2G2A | LMNA 2391/4885EPHX2 140/4885ALDH1A1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.