Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL170880 | 0.86 | RECQL (0.51) | CHRNB2CHRNA4CHRNA7LMNAALDH1A1 | |
| SCHEMBL16625906 | 0.85 | CHRNB2 (0.65) | CHRNB2CHRNA4CHRNA7LMNAALDH1A1 | |
| SCHEMBL26239734 | 0.84 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA7LMNAALDH1A1 | |
| SCHEMBL16606314 | 0.80 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA7CYP1A2CYP2D6 | |
| SCHEMBL13509698 | 0.78 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA7LMNAALDH1A1 | |
| SCHEMBL13995266 | 0.78 | OPRK1 (0.53) | ALDH1A1OPRM1OPRD1OPRK1 | |
| SCHEMBL15699208 | 0.78 | CHRNB2 (0.69) | CHRNB2CHRNA4CHRNA7LMNAALDH1A1 | |
| SCHEMBL7215289 | 0.77 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA7ALDH1A1CYP1A2 | |
| SCHEMBL27928441 | 0.77 | CHRNA7 (0.58) | CHRNB2CHRNA4CHRNA7CYP1A2CYP2D6 | |
| SCHEMBL12197592 | 0.77 | CHRNB2 (0.72) | CHRNB2CHRNA4CHRNA7ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7462625-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2008-12-09 | — | — | US | disclosed |
| US-20070208049-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-09-06 | — | — | US | disclosed |
| US-7179815-B2 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | NEUROCRINE BIOSCIENCES, INC. (US) | 2007-02-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208049-A1 | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto | GNRHR, GHRHR, LHCGR | CHRNB2 503/4885CHRNA4 408/4885CHRNA7 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.