Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HRAS | P01112 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14002824 | 0.89 | HRAS (0.45) | TP53HRASESR1TOP1ESR2 | |
| SCHEMBL20085594 | 0.80 | CCNC (0.48) | BRD4NR4A2PKMCCNCCDK8 | |
| SCHEMBL21180776 | 0.78 | BAZ2B (0.42) | BAZ2BBRD4NR4A2PKMCLK1 | |
| SCHEMBL13527129 | 0.78 | CCNC (0.51) | BRD4PKMCCNCCDK8AR | |
| SCHEMBL781811 | 0.78 | TDP1 (0.45) | PKMCCNCCDK8ESR2AR | |
| SCHEMBL10110884 | 0.78 | CCNC (0.36) | BRD4PKMCCNCCDK8AR | |
| SCHEMBL18773492 | 0.78 | TOP1 (0.41) | BRD4PKMHRASESR1TOP1 | |
| Hydrochloric Acid SCHEMBL7535001 | 0.77 | KDM4E (0.44) | PKMHRASESR1TOP1ESR2 | |
| SCHEMBL13682469 | 0.77 | PKM (0.41) | PKMHRASESR1TOP1ESR2 | |
| SCHEMBL2215169 | 0.77 | CYP1A2 (0.46) | BRD4NR4A2PKMKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | IMMUNOGEN, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-20200397914-A1 | BENZODIAZEPINE DERIVATIVES | IMMUNOGEN, INC. | 2020-12-24 | — | — | US | disclosed |
| US-7449547-B2 | Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate | NAXOPHARMA S.R.L. (IT) | 2008-11-11 | — | — | US | disclosed |
| US-20070060523-A1 | Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate | NAXOSPHARMA S.R.L. (IT) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200397914-A1 | BENZODIAZEPINE DERIVATIVES | GABRA5, GABRA3, GABRA1 | BAZ2B 607/4885BRD4 240/4885NR4A2 582/4885 |
| US-20070060523-A1 | Process for the synthesis of distamycin and derivatives thereof using 1-methyl-4-formylamino-2-pyrrolecarbonyl chloride iteratively as an intermediate | DHPS, PCBP1, MRPL21 | BAZ2B 2943/4885BRD4 154/4885NR4A2 3410/4885 |
| US-11793885-B2 | Substituted benzo[5,6][1,4]diazepino[1,2-a]indoles for the treatment of proliferative disorders | MKI67, GABBR1, GABBR2 | BAZ2B 434/4885BRD4 34/4885NR4A2 741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.